Hoechst Aktiengesellschaft

Richard H Rupp

Bansi Lal

Bimal N Ganguli

Hans-Wolfram Fehlhaber

Noel J De Souza

Alihussein N Dohadwalla

Gerhard Beck

Herbert Kogler

Sugata Chatterjee

Yatendra Khandelwal

Bindumadhavan Venugopalan

Jochen Knolle

Bernward Scholkens

Erra K Vijayakumar

Christopher M Franco

Triptikumar Mukhopadhyay

Kirity Roy

Dipak K Chatterjee

Vijay A Aroskar

Goukanapalli C Reddy

Ramanujam Rajgopalan

Ramchandra G Naik

Martin Bickel

Volker Teetz

Wilhelm Bartmann

Ulrich Lerch

Gerhard Dickneite

Gerhard Seibert

Jurgen Blumbach

Hans H Sedlacek

Swati Bal-Tembe

Pravin J Karnik

Chintamani P Bapat

Julia Gandhi

Ramanujam Rajagopalan

Nandkumar K Dadkar

Samba Laxminarayan Kattige

Greta Moraes

Subramani N Iver

Dipak C Chatterjee

Samina A Dohadwalla

Anis S Dohadwalla

Rashida A Dohadwalla

Deceased AliHussein Dohadwalla

Rajeshwari Kannan

Alihussein Nomanbhai Dohadwalla, Deceased

Narayan Sudhindra Punekar

Sadashiv S Mandrekar

Rajkumar Dhar

Deepak K Chatterjee

Aftab D Lakdawalla

Rajendra K Jani

Sukumar Chatterjee

Ashok K Gangopadbya

Compounds of the formula III ##STR1## in which R.sub.4 and R.sub.5 are CH.sub.3 amd R.sub.6 is hydrogen, have prolonged spasmolytic and anaesthetic activity.

Method of blocking nerve conduction by treatment with branched-chain

Compounds of the formula I ##STR1## in which the substituents R.sub.1 -R.sub.5 and n and m are as defined are suitable for controlling tumors.

Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one

Cammunocin, an active substance which can be obtained by cultivation of Streptomyces species Y-84,36210 (DSM 4329), has antibiotic and immunosuppressant activity.

Antibiotic, cammunocin, a process for the preparation thereof, and the

The present invention relates to labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive ionotropic effect, an effect of lowering intraocular pressure and lowing blood pressure.

Labdane derivatives, a process for their preparation, and their use as

10-substituted ether derivatives of 3.alpha., 12.alpha.-Epoxy-3,4,5 5a.alpha., 6,7,8,8a.alpha.,9,10,12.beta., 12a-dodecahydro-10-hydroxy-3.beta.,6.alpha.,9.beta.-trimethylpyano-(4,3-j) (1,2) benzodioxepin, also known as Dihydroartemisinin or Dihydroquinghaosu (DHQ), pharmaceutically acceptable salts thereof, processes for their preparation and their use as chemotherapeutics against protozoal infections are provided.

10-substituted ether derivatives of dihydroartemisinin, process for

The present invention relates to combinations of the malaria therapeutics artemisinine, dihydroartemisinine, arteether, artemether, artesunate or other artemisinine derivatives with one or more of the antimalarials chloroquine, 10-0-methylfloxacrine, quinine, mefloquine, amodiaquine, pyrimethamine, sulfadoxine and primaquine. Synergistic actions are achieved with them on treatment of mammals, including humans, with subcurative doses of the individual substances.

Pharmaceutical combination for the prophylaxis and therapy of malaria

Labdanes of the formula ##STR1## a process for their manufacture, pharmaceutical preparations containing an effective amount of these compounds and their use for the manufacture of a pharmaceutical preparation for treatment of cardiovascular diseases and high intraocular pressure.

Labdanes and process for their preparation

Pyrimido-(6,1-a)-isoquinolin-4-one derivatives of the formula ##STR1## in which the substituents R.sup.1 -R.sup.6 have the meanings mentioned, are suitable for the prevention of hair loss and for strengthening hair growth.

Use of pyrimido-(6,1-a)-isoquinolin-4-one derivatives and medicinal

A new antibiotic, aranorosin, a microbiological process for the preparation thereof, and the use thereof as a pharmaceutical. Aranorosin, a compound of the formula ##STR1## can be prepared with the aid of the fungus culture Y-30499 (DSM 4151). Aranorosin has an antibiotic action as well as an action against malignant tumors.

Antibiotic, aranorosin, a microbiological process for the preparation

Mersacidin, a cyclic peptide of the formula I ##STR1## has antibiotic activity.

Antibiotic, mersacidin, a process for the preparation thereof and the

The present invention relates to polyoxygenated labdane-derivatives of the formula ##STR1## a process for their preparation and the use of these substances as medicaments, preferably as medicaments having a positive inotropic effect, an effect of lowering intraocular pressure and lowering blood pressure.

Fumifungin, a compound of the formula ##STR1## can be isolated from the culture broth of fungus culture No. Y-83,0405 (DSM 4152), and has bactericidal and fungicidal properties.

Antibiotic, fumifungin, a microbial process for the preparation thereof,

The present invention relates to the macrolide antibiotic swalpamycin, to a microbiological process for its preparation, to a new microorganism strain Streptomyces species, and to the use of swalpamycin as a medicinal agent for the treatment of infections caused by bacteria, mycoplasmas and Actinomycetes.

Macrolide antibiotic and its use as a medicinal agent

The present invention relates to novel 4H-1-benzopyran-4-one derivatives, to processes for the preparation thereof and to their use as anti-inflammatory, analgesic, immuno-suppressive and anti-allergic agents. In particular, the present invention relates to novel compounds of the formula I, ##STR1## in which R.sub.1 is hydrogen, alkyl having 1 to 6 carbon atoms, arly-C.sub.1 -C.sub.4 -alkyl, substituted C.sub.1 -C.sub.6 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkyl-C.sub.1 -C.sub.4 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.3 -C.sub.6 -alkynyl, aryl or carboxyl or an aldehyde or COO--C.sub.1 -C.sub.4 -alkyl group, R.sub.2 is hydrogen, alkyl having 1 to 6 carbon atoms, nitro, amino, di-C.sub.1 -C.sub.4 -alkylamino or a halogen, R.sub.3 is C.sub.1 -C.sub.4 -alkyl, substituted C.sub.1 -C.sub.4 -alkyl, hydroxyl, C.sub.1 -C.sub.4 -alkoxy, aryl-C.sub.1 -C.sub.4 -alkyl, nitro, amino, a C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino group or halogen, R.sub.4 is hydrogen, hydroxyl, C.sub.1 -C.sub.4 -alkyoxy, C.sub.1 -C.sub.4 -alkyoxycarbonyl, aryloxy, amino or a C.sub.1 -C.sub.4 -alkylamino or di-C.sub.1 -C.sub.4 -alkylamino group, R.sub.5 is hydrogen, C.sub.1 -C.sub.6 -alkyl, substituted C.sub.1 -C.sub.6 -alkyl, aryl-C.sub.1 -C.sub.4 -alkyl, C.sub.3 -C.sub.6 -cycloalkyl, C.sub.3 -C.sub.6 -cycloalkyl-C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkanoyl or aroyl, the aryl group being phenyl which is unsubstituted, monosubstituted or polysubstituted, m is an integer between 0 and 3 and n is an integer between 0 and 2, and to pharmacologically acceptable acid addition salts thereof.

4H-1-benzopyran-4-one compounds which have anti-inflamatory or

The present invention relates to novel, 1-substituted 3-aryl-7-chloro-3,4-dihydro-(2H)-acridone N-oxides, a process for their preparation, pharmaceutical compositions containing these compounds, and their use as chemotherapeutic agents, in particular as antimalarials and coccidiostatics.

1-substituted 3-aryl-7-chloro-3,4-dihydro(2H)-acridone N-oxides, a

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Konigstein/Taunus, Germany

Richard H Rupp