American Cyanamid Company

Other

American Home Products Corporation

Richard H Kramss

Eugene J Trybulski

Herbert J Brabander

Gaetan H Ladouceur

Donald J Wolanin

James H Cook, Ii

Timothy G Lease

Martin H Osterhout

Donald L Hertzog

William R Schoen

Substituted biphenyls having glucagon receptor antagonistic activity. Claimed compounds have the formula

Substituted biphenyls

This disclosure describes novel substituted oxotremorine derivatives of formula I having nitrogen, oxygen or sulfur groups and the prodrug forms of these derivatives. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and the processes for the production of the compounds. ##STR1##

Substituted oxotremorine derivatives

Substituted oxotremorine derivatives and pharmaceutical use thereof

Compounds of the formula: ##STR1## wherein A is t-butoxy carbonyl, which compounds are useful as intermediates for preparing 1-Substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives having cholinergic agonist activity.

Dibromovinyl and acetylene-1-pyrrolidinecarboxylic acid intermediates

This disclosure describes novel 3 or 4 substituted oxotremorine derivatives having polar substituted oxygen or sulfur groups. The compounds have cholinergic activity. Also disclosed are methods for treating diseases of the central nervous system in mammals employing the compounds, pharmaceutical preparations containing the compounds and processes for the production of the compounds.

3- or 4-substituted oxotremorine derivatives and a method of treating

Compounds of the formula: ##STR1## pharmaceutical compositions containing the compounds and methods of using the compounds in the treatment of central cholinergic disfunction in a mammal are disclosed.

1-substituted-2-(3-amino-1-propynyl)pyrrolidine derivatives

3- or 4-substituted oxotremorine derivatives

Growing community of inventors

Newburgh, NY, United States of America

Richard H Kramss