University of California

Other

Cygnus Therapeutic Systems

Massachusetts Institute of Technology

Cygnus, Inc.

Richard H Guy

Paul R Stauffer

Gordon L Flynn

Girish Rao

Hirohisa Okuyama

Durairaj Bommannan

Christopher Cullander

Robert S Hinz

Peretz Glikfeld

Robert Samuel Langer

Mark R Prausnitz

James C Weaver

Uwe Pliquett

Rita Vanbever

Thomas E Zewert

Tani Chen

Method for the iontophoretic non-invasive determination of the in vivo concentration level of an inorganic or organic substance

A method of modifying epidermis for transport of a material by electroporation includes applying to epidermis an agent that, upon entry into the epidermis, will modify the epidermis to thereby cause and altered rate of transport of a material across the epidermis. Typically, the altered rate will be an increased rate of transport. The epidermis is electroporated, whereby at least a portion of the modifying agent enters the electroporated epidermis, thereby modifying the epidermis to cause an altered rate of transport of a material across the epidermis. In another embodiment, the modifying agent can modify the epidermis to enable measurement and/or monitoring of physiological conditions or change within or beneath the epidermis. The modifying agents can also be employed to facilitate discharge of fluids from within an organism, such as by providing pathways for discharge of fluids from a tumor. Examples of modifying agents include: oxidizing agents; reducing agents; particles, such as optical indicator beads or beads that include drugs to be released into tissue; electrically-charged particles or molecules; etc. Materials that can be transported by the method of the invention include, for example, proteins, nucleic acids, electrically charged molecules or particles, microorganisms suitable for immunization, etc. Also, tissues other than skin can be employed in the method of the invention.

Introduction of modifying agents into skin by electroporation

The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises:

Method for the iontophoretic non-invasive determination of the in vivo

A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultra sound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.

Ultrasound-enhanced sampling of materials through the skin

Method for the iontophoretic non-invasive-determination of the in vivo

A method for enhancing the permeability of the skin or other biological membrane to a material such as a drug is disclosed. In the method, the drug is delivered in conjunction with ultrasound having a frequency of above about 10 MHz. The method may also be used in conjunction with chemical permeation enhancers and/or with iontophoresis.

Ultrasound-enhanced delivery of materials into and through the skin

Device for iontophoretic non-invasive sampling or delivery of substances

A foldable-screen room divider in combination with a curio cabinet, wherein the room divider is defined by at least three screen sections, the central or intermediate screen section having a curio cabinet mounted thereon, so as to allow ornamental objects or articles to be stored and displayed. The curio cabinet can be mounted in two modes. In one arrangement, the cabinet is hinged to the center screen section for access to the section having a transparent panel. In the other arrangement, the curio cabinet is fixed to the screen section which has a hinged door provided with a transparent panel for viewing the interior of the curio cabinet. The side screen sections are hinged to the central section and can be adapted with ornamental panels.

Combination foldable-screen room divider and curio cabinet

Extruded molding

A frame-positioning device for mounting and stretching canvas and like materials that must be stretch-mounted to a supporting stretcher-frame structure, generally comprising a four-sided wooden frame member, whereby the canvas is stapled thereto. The frame-positioning means includes a pair of stretcher bar holders which are arranged to be slidably received on the structural-beam member of a canvas-stretching-and-mounting apparatus, so as to be adjustable in vertical and horizontal planes along the beam to accommodate various sizes of frames.

Frame-positioning device for mounting canvas and like material

An apparatus for stretching canvas and like materials that must be stretch-mounted to a supporting stretcher-frame structure generally comprising a four-sided wooden frame member, whereby the canvas is stapled thereto. The apparatus comprises an elongated, horizontal, tubular, structural-beam member affixed at both ends to vertical supports; and has an elongated, biased, clamping bar member hingedly mounted along the full length of the upper surface of the structural-beam member, the clamping bar being provided with a canvas-securing keeper located thereon to engage, under tension, one edge of the canvas when the canvas is positioned between the clamping bar and the beam member. The operation of the clamping bar is provided by a spring-loaded handle and a trigger-release device, the trigger-release device being adapted to be adjustably positioned on either side of the canvas-stretcher frame during the operation thereof. Further included is a pair of stretcher-bar holders which are arranged to be slidably received on the beam member and to be adjustable to support various sizes of stretcher frames.

Apparatus for stretching canvas and like materials

Growing community of inventors

San Francisco, CA, United States of America

Richard H Guy