3M Innovative Properties Company

Richard H Ferber

Michael D Delmore

Patrick R Fleming

Eugene G Joseph

Donald R Battles

Jamieson C Keister

Joseph A Tucker

Michael K Domroese

Graham M Clarke

Cristina U Thomas

Franklyn L Frederickson

Luther E Erickson

Myhanh T Truong

David J Velasquez

Douglas A Huntley

Hye-Ok Choi

James K Young

Kaveh Pournoor

Stephanie F Bernatchez

Jay D Jacobs

Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.

Microneedle devices and microneedle delivery apparatus

Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

Microneedle devices and methods of manufacture

Microneedle arrays, methods of manufacturing microneedles and methods of using microneedle arrays. The microneedles in the microneedle arrays may be in the form of tapered structures that include at least one channel formed in the outside surface of each microneedle. The microneedles may have bases that are elongated in one direction. The channels in microneedles with elongated bases may extend from one of the ends of the elongated bases towards the tips of the microneedles. The channels formed along the sides of the microneedles may optionally be terminated short of the tips of the microneedles. The microneedle arrays may also include conduit structures formed on the surface of the substrate on which the microneedle array is located. The channels in the microneedles may be in fluid communication with the conduit structures. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and/or extract blood or tissue.

Microneedle arrays and methods of manufacturing the same

A preformed object for delivering an active agent for a subject, the preformed object including crosslinked protein, and methods of making and using.

Delivery systems using preformed biodegradable polymer compositions and methods

A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40&deg; C.) of at least 1000 g/m /day, preferably at least 6000 g/m /day.

Low trauma adhesive article

A low trauma pressure-sensitive adhesive coated substrate comprising a sheet material, tape or laminate structure designed to adhere to skin or like surfaces. The pressure-sensitive adhesive layer of this adhesive coated substrate is a fibrous adhesive layer generally having a basis weight of from 5 to 200 g/m,applied to a conformable backing or substrate. The fibrous adhesive layer has a textured outer face and persistent porosity between discrete adhesive fibers. Generally, the fibrous adhesive layer has a MVTR (measured by ASTM E 96-80 at 40&deg; C.) of at least 1000 g/m,/day, preferably at least 6000 g/m,/day.

Growing community of inventors

Fridley, MN, United States of America

Richard H Ferber