Abbott Laboratories Corporation

Richard H Decker

William Frederick Carman

Larry T Mimms

Larry R Solomon

Lesley Wallace

Chung-Mei Ling

John A Weare

Isa K Mushahwar

Lacy R Overby

Ruben Chairez

Karen V Stuckmann

The invention is an improved immunoassay and method for detection of antibody to hepatitis B core antigen (anti-HBc). The improved assay comprises the addition of a reducing agent to decrease the number of false positive reactions in the assay.

Method for increasing specificity in competitive immunoassays

Mutant Hepatitis B Virus (HBV) nucleic acid sequences useful for a variety of diagnostic and therapeutic applications, kits for using the HBV nucleic acid sequences, HBV immunogenic particles, and a method for producing antibodies to HBV. Also provided are methods for producing antibodies, polyclonal or monoclonal, from the HBV nucleic acid sequences.

Hepatitis B virus mutants, reagents and methods for detection

A biotin-antibiotin immunoassay comprises coating a solid phase with a ligand-specific binding material, reacting the solid phase with a test sample, reacting the solid phase with the biotin-labeled form of the ligand-specific binding material and antibiotin labeled with a suitable marker. The marker is then measured to detect the amount of ligand present in the test sample.

Immunoassay for the detection of ligands

Hepatitis B Virus mutants, reagents and methods for detection

The present invention encompasses a method for determining a class specific antibody to an antigen comprising:

Immunoassay for class specific antibodies

The present invention encompasses an improved method for detecting antigen or antibody bound to a solid support which involves the reaction of hapten-labeled antibody to the antigen or antibody to be detected followed by reaction of the hapten moiety with labeled antibody to the hapten and the determination of the amount of label bound to the solid support.

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Deerfield, IL, United States of America

Richard H Decker