Palo Alto Research Center Inc.

Xerox Corporation

The Scripps Research Institute

Sri International

Palo Alto Research Institute Incorporated

Richard H Bruce

Scott Alan Elrod

Francisco Eduardo Torres

Eric Peeters

Alan G Bell

Louis D Silverstein

Alan G Lewis

Huangpin Ben Hsieh

Peter Kiesel

Robert Arthur Sprague

Douglas N Curry

Babur B Hadimioglu

Jaan Noolandi

David A Horine

Robert Thomas Krivacic

Michael Bassler

Noble Marshall Johnson

Meng H Lean

Jeffrey N Roe

Joerg Martini

Michael L Chabinyc

John Stuart Fitch

Armin Rainer Völkel

Michael G Hack

Russel A Martin

Joy Roy

William D Turner

Michael I Recht

David Kalman Biegelsen

Warren Bruce Jackson

Raj B Apte

Daniel H Greene

Andrew A Berlin

Thomas P Moran

Dirk De Bruyker

Daniel Senderowicz

Marc E Mosko

Richard A Lerner

Armin R Volkel

Bryan Thomas Preas

William F Gunning

Thomas G Fiske

Malcolm J Thompson

Jean A Gastinel

Michael Overton

Frank Torres

Oliver Schmidt

Lars-Erik Swartz

Jackson H Ho

Patrick C Cheung

Richard J Goldstein

Teresa F Lunt

Michal V Wolkin

Philippe J Golle

Dallas R Grove

Frank G Halasz

Malcolm S Smith

David Eric Schwartz

Daniel Lynn Larner

Ana Claudia Arias

Jessica Nicola Staddon

Steven Rosenberg

Gregory B Anderson

Ross D Bringans

James C Mikkelsen

Ronald T Fulks

Nitin S Parekh

William W Yao

H Ben Hsieh

Hugo L Steemers

Lawrence Lee

Tzu-Chin Chuang

Peter Kuhn

Victor M DaCosta

Robert R Allen, Deceased

William P Meuli

Celia Chow

Rodney Turner

Kathryn M Middo

Bo Begole

Susan M Stuber

Lisa Fahey

Linda Jacobson

Susan (Susie) Mulhern

David Weinerth

Nicole H Lazarus

James R Williamson

Ray Stevens

Ben H Hsieh

Nicole Hanson Lazarus

An implantable product such as an article, device, or system can include analyte and non-analyte containers in parts that can be operated as optical cavities. The product can also include fluidic components such as filter assemblies that control transfer of objects that affect or shift spectrum features or characteristics such as by shifting transmission mode peaks or reflection mode valleys, shifting phase, reducing maxima or contrast, or increasing intermediate intensity width such as full width half maximum (FWHM). Analyte, e.g. glucose molecules, can be predominantly included in a set of objects that transfer more rapidly into the analyte container than other objects, and can have a negligible or zero rate of transfer into the non-analyte container; objects that transfer more rapidly into the non-analyte container can include objects smaller than the analyte or molecules of a set of selected types, including, e.g., sodium chloride. Output light from the containers accordingly includes information about analyte.

Controlling transfer of objects affecting optical characteristics

A system and method is provided for detecting concentration of an analyte in a fluid. A first container includes (i) an optical cavity detection region, (ii) a reservoir for one or more modifiers of one or more optical properties of the optical cavity detection region, and (iii) a set of one or more bounding regions through which objects in the fluid can transfer into the container. The optical cavity detection region and the reservoir define separate areas of the first container. The movement of the one or more modifiers between the reservoir and the optical cavity detection region is responsive to changes in concentration of the analyte. A second container includes an optical cavity detection region, and a set of one or more bounding regions through which objects in the fluid can transfer into the container. Also provided are optical components for guiding light into the optical cavity detection regions of the first and second containers.

Specificity of analyte detection in etalons

An analyzer includes a flow cell having a flow channel through which a sample passes. A light source excites at least a first particle type in the sample in one or more excitation region(s), and a detector detects light emitted by the excited particle. A spatial filter defines detection regions, wherein light emitted by the particle is transmitted to the detector, and interspersed shielded regions, wherein such light is at least partially blocked from reaching the detector. The light emitted by the excited particle has a response time &#x3c4;, and the sample may also contain a component that is excited by the light source and that has a response time &#x3c4;. The excitation region(s) and the detection regions are arranged to provide a time delay between excitation and detection, the time delay tailored to isolate light emitted by the first particle from light emitted by the component.

Particle analyzer with spatial modulation and long lifetime bioprobes

A method and system for affecting a thrombus after ischemic stroke. The method may include injecting a plurality of magnetic particles into a bloodstream and moving or distorting a thrombus formed or lodged in the bloodstream using a magnetic force to manipulate the magnetic particles. The method may include conjugating ferromagnetic particles, paramagnetic particles, or superparamagnetic particles to a thrombus-specific attachment agent such as an anti-fibrin antibody, and injecting the conjugated particles into the bloodstream. Thereafter, the thrombus may be agitated, broken apart, or dissolved using a magnetic field to exert a magnetic force on the conjugated particles. The method may also include injecting a thrombolytic agent into the bloodstream to interact with and further dissolve the thrombus.

Method and apparatus for thrombus removal using magnetic particles

An implantable product includes an optical cavity structure with first and second parts, each of which can operate as an optical cavity. The first part includes a container with at least one opening through which bodily fluid can transfer between the container's interior and exterior when the product is implanted in a body. The second part includes a container that is closed and contains a reference fluid. The implantable product can also include one or both of a light source component and a photosensing component. Photosensed quantities from the first part's output light can be adjusted based on photosensed quantities from the second part's output light. Both parts can have their light interface surfaces aligned so that they both receive input light from a light source component and both provide output light to a photosensing component.

Implanting optical cavity structures

A system and method is provided for detecting concentration of an analyte in a fluid. The method comprises detecting an optical property of a first region of two or more regions in a system, the first region located in a container having a reservoir for one or more modifiers of one or more optical properties of the first region. The movement of the one or more modifiers is responsive to changes in concentration of the analyte. A next step detects an optical property of a second region of the two or more regions in the system, the second region located in a container having a reservoir for one or more modifiers of one or more optical properties of the second region. The movement of the one or more modifiers is responsive to changes in concentration of a compound, where the compound is something other than the analyte. The detected optical property of the first region and the detected optical property of the second region are used in embodiments to separate the effect of the analyte on the detected optical property of the first region from the effect of the compound, where the compound is an interfering compound.

Method of detecting the concentration of an analyte

A system and method for providing print advertisements is presented. A target audience is assembled from characteristics about readers. Advertising content is targeted to the target audience. The characteristics of the target audience are analyzed against the advertising content to identify potential advertisers. At least one of the potential advertisers is selected. At least one print advertisement for the selected advertiser is included on the document.

System and method for providing print advertisements

A detection system includes a detection device and an anti-evaporation device. The detection device comprises a region configured to merge at least two small drops and to detect a potential transient signal generated by the merger of the drops. The an anti-evaporation is configured to enclose the region and limit evaporation from the region. A method for detecting a signal includes the following steps: depositing drops of potentially reactive chemical solutions on a detection device within a drop-merging region; placing an anti-evaporation device over the drop-merging region to form a seal around the drop-merging region; merging the drops of potentially reactive chemical solutions; and measuring a signal occurring within the merged solution drops.

Use of physical barriers to minimize evaporative heat losses

A method is provided for preparing a sample containing potential cells of interest and of using a laser of a laser based system for novel excitation and emission collection, and data usage including use of obtained data for direct and ratio based measurements. The prepared sample is configured to emit signals having spectral characteristics sufficient to permit filtering to differentiate and eliminate most false positives from true positives among acquired imaging events, in an imaging system employing a laser spot having a range of diameters from 1 to 20 &#x3bc;m or greater and which excites the fluorescence in a conventional or novel manner. These filtered events may be subsequently imaged and confirmed with another higher resolution device such as a fluorescent microscope in a short amount of time.

Immunocytostaining methods for enhanced dye ratio discrimination in rare event detection

Thermal sensing devices can include two subsets of thermal sensors connected in a bridge by circuitry on the same support layer or surface with the sensors. Each thermal sensor can be formed in a patterned layer of semiconductor material, and the bridge circuitry can include leads formed in a patterned layer of conductive material, over or under the semiconductor layer. In one implementation, the bridge circuitry includes conductive portions that extend across and electrically contact the lower surface of each sensor's semiconductor slab. The bridge circuitry can also include pads that can be electrically contacted, such as by pogo pins. The device's reaction surface can be spaced apart from or over the thermal sensors. The device's components can be shaped and positioned so that the bridge's offset voltage is below the sensitivity level required for an application, such as by left-right symmetry about an axis.

Thermal sensing with bridge circuitry

Techniques for providing privacy protection are provided. A query is received. Privacy policy information, extracted knowledge and optional information about available public information are determined. Information about the knowledge extraction transformations applied to create the extracted knowledge and the source data is determined. Privacy protecting transformations are determined and applied to transform the extracted knowledge based on the selected privacy policy, optional information about available public information, the characteristics of the applied knowledge extractions transformations, the source data and optional previous user queries.

Systems and methods for protecting privacy

Thermal detectors and thermal sensing cells can include a region of a support layer or support structure. Within the region can be reaction surfaces or other reaction regions, as well as contact pads and circuitry connecting the contact pads to other components. Also, a cell region can include a structure with reaction regions, contact pads, and control/detection circuitry connected to the contact pads; the control/detection circuitry controls occurrence of reactions in response to control signals, such as by drop merging, and also allows electrical detection of thermal signals from the reaction regions. The control/detection circuitry can include reaction control components such as drop merger electrodes and also thermal sensors such as thermistors, or it can include control/sensor elements such as semiconductor slabs that perform both functions. Each cell in an array can have control/detection circuitry that does not extend or connect outside the cell except through contact pads.

Thermal sensing device

Provided is a method of detecting characteristics of a reaction of interest, including instituting the reaction of interest, obtaining an amplified heat related to the reaction of interest, measuring the amplified heat, and determining the characteristics of the reaction of interest, using the signal obtained in the step of measuring.

Amplification of enzymatic reactions for use with an enthalpy array

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Los Altos, CA, United States of America

Richard H Bruce