Eli Lilly and Company

Dow Agrosciences LLC

Other

Richard H Baltz

Patricia J Solenberg

Eugene T Seno

Patti J Treadway

Gene M Wild

Jan R Turner

Donald J Merlo

Clive Waldron

M Christine Broughton

Kathryn P Crawford

Krishnamurthy Madduri

Herbert A Kirst

David S Fukuda

Veronica M Krupinski

Robert L Hamill

Jo Ann Hoskins

R Nagaraja Rao

Richard K Stanzak

Margaret M Ballou

Margaret A McHenney

Gerald L Huff

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme ofAlso provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

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Spinosyn biosynthetic genes fromspinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.

DNA encoding SPNF of the spinosyn cluster

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of . Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

Glycosyltransferase gene gtfE from Amycolatopsis oreintalis

Spinosyn biosynthetic genes from , spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms are provided.

SpnG, a gene for spinosyn insecticide biosynthesis

Spinosyn biosynthetic genes, spinosyn producing microorganisms transformed with the biosynthetic genes, methods using the biosynthetic genes to increase production of spinosyn insecticidal macrolides, and methods using the genes or fragments thereof to change the products produced by spinosyn-producing microorganisms.

Biosynthetic genes for spinosyn insecticide production

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of,Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

Glucosyltransferase gene gtfe from Amycolatopsis orientalis

The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfA of Amycolatopsis orientalis. Also provided are vectors carrying the gtfA gene, transformed heterologous host cells for expressing the GtfA protein, and methods for producing glycopeptide compounds using the cloned gtfA gene.

Glycosyltransferase gene gtfA from Amycolatopsis orientalis

The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfC of Amycolatopsis orientalis. Also provided are vectors carrying the gtfC gene, transformed heterologous host cells for expressing the GtfC protein, and methods for producing glycopeptide compounds using the cloned gtfC gene.

Glycosyltransferase gene gtfC from Amycolatopsis orientalis

The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfD of Amycolatopsis orientalis. Also provided are vectors carrying the gtfD gene, transformed heterologous host cells for expressing the GtfD protein, and methods for producing glycopeptide compounds using the cloned gtfD gene.

Glycosyltransferase gene GFTD from amycolatopsis orientalis

The invention provides isolated nucleic acid compounds encoding the glycosyltransferase protein GtfB of Amycolatopsis orientalis. Also provided are vectors carrying the gtfB gene, transformed heterologous host cells for expressing the GtfB protein, and methods for producing glycopeptide compounds using the cloned gtfB gene.

Glycosyltransferase gene gtfB from Amycolatopsis orientalis

Provided herein is a method to produce knockout mutations at targeted sites in the genome of Streptococcus pneumoniae.

Method for knockout mutagenesis in Streptococcus pneumoniae

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode the enzyme, transformed heterologous host cells for expressing the enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode the enzyme.

Glucosltransferase gene GTFE from amycolatopsis orientalis

The invention provides isolated nucleic acid compounds encoding a glycosyltransferase enzyme of Amycolatopsis orientalis. Also provided are vectors carrying genes that encode said enzyme, transformed heterologous host cells for expressing said enzyme, and methods for producing glycopeptide compounds using the cloned genes that encode said enzyme.

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Indianapolis, IN, United States of America

Richard H Baltz