Abbott Laboratories Corporation

Richard G Kendall

John W Roche

Giacomo Vacca

Mahesh R Junnarkar

Michael W Yee

Norman R Goldblatt

Roger W Accurso

Jiong Wu

Mahmoud Janbakhsh

Svitlana Y Berezhna

Michael J Kennedy

Ronald J Shanafelter

Daryl Wong

Trevor David Shields

Robert John Fahey

Thomas V Schisano

James A Janik

Jorge Haro

A method for counting blood cells in a sample of whole blood. The method comprises the steps of:

Method for performing a blood count and determining the morphology of a blood smear

Aspects of the present disclosure include systems and methods. According to certain embodiments, provided is an integrated analysis system that includes a first module including a sample analysis component and a first internal container conveyor system. The integrated analysis system further includes a second module including a second internal container conveyor system. The first and second modules are positioned adjacent each other such that the first and second internal container conveyor systems are aligned and adapted to transport containers from the first module to the second module. Also provided are methods of analyzing and preparing samples (e.g., blood and body fluid samples), as well as components that find use within the analysis systems of the present disclosure.

Systems and methods for automated analysis

A method for counting blood cells in a sample of whole blood. The method comprises the steps of: Optionally, steps of fixing and staining of blood cells on the slide can be employed in the method.

A method for increasing the throughput and/or the precision of a flow cytometer, or a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer. The system and method includes utilizing the technique of laser rastering in combination with a lysis-free single-dilution method.

Method and apparatus for rapidly counting and identifying biological particles in a flow stream

A method for increasing the throughput, or the precision, or both the precision and the throughput, of a flow cytometer, or of a hematology analyzer employing a flow cytometer, and for further reducing the complexity of such a cytometer or analyzer, by utilizing the technique of laser rastering in combination with a lysis-free single-dilution method. Laser rastering involves sweeping a laser beam across a flowing sample stream in a hematology analyzer. A lysis-free single-dilution method involves performing all the flow cytometer measurements on a sample using a single aliquot, a single lysis-free reagent solution, a single dilution, and a single pass of said dilution through the measurement apparatus. An apparatus suitable for carrying out the method of this invention comprises an optical module comprising a source of light, a scanning device, a lens or system of lenses, a flowcell, detectors, and filters; and an electronic module comprising preamplifiers, analog signal conditioning elements, analog-to-digital converters, field-programmable gate arrays, digital signal processing elements, and data storage elements.

A method for determining the value of MCV of a fresh sample of blood when the value of MCV for that sample of blood is known, but the period of time that the sample of blood has been stored is not known. The method of this invention allows an automated hematology analyzer to provide a more reliable indication of the initial value of MCV of a sample of blood, i.e., the value of MCV that would have been expected for the sample of blood when the sample was fresh. Furthermore, the method of this invention uses data that is readily available as part of the blood count data.

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Miami, FL, United States of America

Richard G Kendall