Philadelphia Health and Education Corporation

University of California

Richard F Rest

Michael Karin

Jin Mo Park

Daniel J Simon

Elise M Mosser

The invention provides a novel gene and protein regulating the expression ofAnthrolysin O toxin, pharmaceutical compositions and antibodies which may be utilized for human or veterinary applications or for agricultural applications, and methods of treatment using same.

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Compounds, methods for identifying compounds and methods for using compounds which modulate interaction of lethal factor and anthrolysin O in the treatment and prevention of anthrax diseases are provided.

Compositions and methods for preventing and treating anthrax diseases

Methods for activating Toll-like receptor 4 via cholesterol-dependent cytolysins isolated from a Gram-positive bacteria are provided. In addition compositions containing an isolated cholesterol-dependent cytolysin or a fragment thereof or a mimetic of the cytolysin or fragment thereof and methods for use of such composition in inhibiting binding and/or interaction of Toll-like receptor 4 with endotoxin are provided. Methods for identifying modulators of Toll-like receptor 4 activation by a cholesterol-dependent cytolysin and use of such modulators in treatment of septicemia and/or septic shock are also provided.

Growing community of inventors

Rosemont, PA, United States of America

Richard F Rest