Aventis Pharmaceuticals Inc.

Aventis Pharmaceuticals Products Inc.

Aventis Pharma Deutschland, Gmbh

Oscient Pharmaceuticals Corporation

Foldrx Pharmaceuticals, Inc.

Richard F Labaudiniere

Joseph M Salvino

George C Morton

Robert D Groneberg

Helen J Mason

Gerard M McGeehan

Daniel Gerard McGarry

Mark A Bobko

Anne Minnich

Litao Zhang

Michael F Kelley

Zaid Jayyosi

Christopher J Burns

Robert L Morris

Gregory Bernard Poli

Benoit J Vanasse

Thomas Caulfield

Matthew M Morrissette

Clarence C Morse

Liang Ma

Giorgio Mosconi

Daniela Jabes

Gregg R Crumley

Christopher Hulme

Rose Mappilakunnel Mathew

John E Airey

Stephen Condon

Franco Manfre

Kin T Yu

Fran&ccedil;ois-Fr&eacute;d&eacute;ric Clerc

Daniel No&euml;l Andr&eacute; Bezard

Timothy S Leach

Thomas J Caulfield

Steven M Rauscher

Marie-Pierre Cherrier

Compounds, compositions and methods are provided for stabilizing transthyretin and for treating, preventing, or ameliorating one or more symptoms of transthyretin mediated diseases. In one embodiment, the compounds are benzoxazoles and related compounds.

Compounds, compositions and methods for stabilizing transthyretin and inhibiting transthyretin misfolding

The invention features a method of treating or preventing a disease associated with the use of antibiotics in a patient in need thereof by administering to the patient ramoplanin in an amount and for a duration effective to treat said disease. The disease may be caused, for example, by the presence of a bacterium such as enterotoxin producing strains of, or

Use of ramoplanin to treat diseases associated with the use of antibiotics

The use of triaryl acid derivatives of formula (I)and their pharmaceutical compositions as PPAR ligand receptor binders. The PPAR ligand receptor binders of this invention are useful as agonists or antagonists of the PPAR receptor.

Therapeutic uses of tri-aryl acid derivatives

This invention is directed to a bioassay for determining the functionality of parathyroid hormone compounds. More particularly, this invention is directed to a bioassay wherein the compound to be tested is added to a culture of parathyroid hormone receptor expressing cells bearing a reporter gene under the transcriptional control of multiple c-AMP responsive elements.

Luciferase reporter bioassay of parathyroid hormone compounds

This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;,&bgr;-unsaturated carboxylic acid and aldehyde compounds

This invention is directed to a fluorophenyl resin compound, to methods of its preparation; and to its use in the solid phase synthesis of amides, peptides, hydroxamic acids, amines, urethanes, carbonates carbamates, sulfonamides and &agr;-substituted carbonyl compounds.

Fluorophenyl resin compounds

Therapeutic uses of di-aryl acid derivatives

A method for preparing a N-&lsqb;(aliphatic or aromatic)carbonyl)&rsqb;-2-aminoacetamide compound, and for preparing a cyclized compound therefrom, as well as novel resin bound intermediate compounds that are useful for preparing such compounds.

Methods for preparing N-&lsqb;(aliphatic or aromatic)carbonyl)&rsqb;-2-aminoaetamide compounds and for cyclizing such compounds

Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and &agr;&bgr;-unsaturated carboxylic acid and aldehyde compounds

This invention relates to compounds of general formula (I):

Substituted &bgr;-thiocarboxylic acids

This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and .alpha.,.beta.-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

Process for the solid phase synthesis of aldehyde, ketone, oxime, amine,

This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR.sup.1 ; and R.sup.1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.

Functionalized resin for the synthesis of amides and peptides

Growing community of inventors

Collegeville, PA, United States of America

Richard F Labaudiniere