Bayer Aktiengesellschaft

Miles Inc.

Bayer Corporation

Miles Laboratories, Inc.

Richard F Hector

Klaus Schaller

Heinrich F Moeschler

Manfred Plempel

Manfred Blempel

Michael S Collins

Bacterial meningitis infection in a mammal is treated by intravenous infusion of a therapeutically effective amount of a monoclonal antibody which binds to tumor necrosis factor alpha and an antibiotic. Treatment can be initiated up to five hours after bacterial challenge and the antibiotic is preferably selected from cephalosporins and aminoglycosides.

Method of treating bacterial meningitis with anti-tumor necrosis factor

Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a synergistic anti-fungal effect.

Antimycotic compositions of nikkomycin compounds and azole antimycotics

The nikkomycin compound possessing antimycotic activity and having the following structure: ##STR1##

Nikkomycin derivatives

Nikkomycin derivatives have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a synergistic anti-fungal effect.

A fungicidal composition comprising a nikkomycin and an echinocandin B. Method of treating a fungal infection comprising administering therapeutically effective amounts of a combination of the nikkomycin and the echinocandin B. Composition and method are especially useful in treating infections of filamentous fungi. Combination of nikkomycin Z and cilofungin found to be synergistic against aspergillosis.

Synergistic fungicidal composition

A method of treating a mammal infected with a dimorphic, highly chitinous fungi, the method comprising administering to the mammal therapeutically effective amounts of a nikkomycin derivative having the following structure: ##STR1##

Method for treating fungal infections with nikkomycin derivatives

Nikkomycin compounds have been found to be orally or parenterally effective as anti-fungals in animals. They may be used alone or, preferably, in combination with azole antimycotics for a snyergistic anti-fungal effect.

Antimycotic compositions of nikkomycin compounds and azole antimycotica

Nikkomycin derivatives, antimycotic compositions of nikkomycin

Method of treating an infection of dimorphic, highly chitinous fungi, the method comprising administering therapeutically effective amounts of a nikkomycin or derivative thereof. Treatment is especially suited for infections of medically significant fungi having cell walls with about 10-20% by weight chitin in the parasitic phase. Such fungi include Coccidiodes immitis, Histoplasma capsulatum, Blastomyces dermatitidis, and Paracoccidiodes brasiliensis.

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Dublin, CA, United States of America

Richard F Hector