Astrazeneca Ab

Richard Evans

Piotr Antoni Raubo

Brian Springthorpe

Timothy Jon Luker

Matthew Wd Perry

Stephen Brough

Stephen Thom

Roger Victor Bonnert

Stephen Connolly

Thomas McInally

Paul Andrew Willis

Andrew Baxter

Anthony Ronald Cook

Rhonan Lee Ford

Barrie Martin

Toby Thompson

Christine Eyssade

Nicholas Kindor

David Harden

David Marriott

The present invention relates to pyrazinone derivatives of formula (I): wherein R, R, R, R, R, Rand Rare as herein defined; processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Pyrazinone derivatives, pharmaceutically acceptance salts thereof and their uses

N-cyclopropyl-3-fluoro-5-[3-[[1-[2-[2- [(2-hydroxethyl)amino] ethoxy]phenyl] cyclopropyl] amino]-2-oxo-1 (2H)-pyrazinyl]-4-methyl-benzamide, or pharmaceutically acceptable salts thereof and their uses

Compounds and their uses 708

The present invention provides a compound of formula (I) wherein W, R, Rand Rare as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

N-(2-(2-(5-hydroxy-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-8-yl)ethylamino)ethyl)-3-(phenethoxy)propanamide derivatives, processes for their preparation, pharmaceutical compositions containing them and their use in therapy

The invention provides compounds of formula (IA), processes for their preparation, pharmaceutical compositions containing them, and their use in therapy. 

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The invention provides a compound of formula (I), wherein: T is C(O) or S(O); W is C(O) or S(O); X is CH, O or NH; Y is CRor N; Ris optionally substituted aryl or optionally substituted heterocyclyl; Ris hydrogen or Calkyl; Ris hydrogen or optionally substituted Calkyl; and Ris alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis 

Piperidine derivatives useful as modulators of chemokine receptor activity

The invention provides compounds of formula (I) wherein: T is C(O) or S(O); W is C(O) or S(O); X is CH, O or NH; Y is CRor N; n is 0, 1 or 2; m is 1 or, when Y is CRm is 0; Ris optionally substituted aryl or optionally substituted heterocyclyl; R, R, R,, R, R, Rand Rare, independently, hydrogen or C?1-6#191 alkyl; Ris hydrogen or C-Calkyl; Ris alkyl, optionally substituted aryl, optionally substituted aralkyl or optionally substituted heterocyclyl; and Ris hydrogen or C-Callkyl; that are modulators of chemokine (especially CCR3) activity and are especially useful for treating asthma and/or rhinitis.

The invention provides compounds of formula (I) wherein R, R, R, R, Z, Q, m, n, X, X, X, Xand T are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them, and their use in therapy, especially for the treatment of chemokine receptor related diseases and conditions

Substituted piperidine compounds useful as modulators of chemokine receptor activity

Growing community of inventors

Loughborough, United Kingdom

Richard Evans