Oxagen Limited

Atopix Therapeutics Limited

Ramot at Tel-aviv University Ltd.

Richard Edward Armer

Graham Michael Wynne

Julia Vile

Mark Whittaker

Eric Roy Pettipher

Frank Schroer

Colin Richard Dorgan

Peter David Johnson

Edward Andrew Boyd

Simon John Edwards

Nawaz Mohammed Khan

Simon David Edwards

Judith Helen Boyd, Legal Representative

Mohammed Nawaz Khan

Meriel Ruth Kimberley

Ruth Meriel Kimberley

Carole Eliane Andree Maillol

Philip Andrew Hay

Compounds of formula (I): and pharmacologically acceptable salts and pro-drugs thereof, wherein the variables are as defined in the specification, are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as pain, lower urinary tract disorders and the like.

Potassium ion channel modulators and uses thereof

Compounds of formula (I) and pharmacologically acceptable salts and pro-drugs thereof wherein: 

Compounds of general formula (II) wherein

Compounds having CRTH2 antagonist activity

Compounds of general formula (I) whereinW is chloro or fluoro;Ris phenyl optionally substituted with one or more substituents, selected from halo, &#x2014;CN, &#x2014;C-Calkyl, &#x2014;SOR, &#x2014;SOR, &#x2014;SON(R), &#x2014;N(R), &#x2014;NRC(O)R, &#x2014;COR, &#x2014;CONRR, &#x2014;NO, &#x2014;OR, &#x2014;SR, &#x2014;O(CH)OR, or &#x2014;O(CH)O(CH)ORwherein

Compounds of general formula (I) wherein R is phenyl optionally substituted with one or more halo substituents; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in orally administrable compositions for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. 

1-acetic acid-indole derivatives with PGD2 antagonist activity

Compounds of general formula (II) whereinW is chloro or fluoro;Ris phenyl optionally substituted with one or more substituents, selected from halo, &#x2014;CN, &#x2014;C-Calkyl, &#x2014;SOR, &#x2014;SOR, &#x2014;SON(R), &#x2014;N(R), &#x2014;NRC(O)R, &#x2014;COR, &#x2014;CONRR, &#x2014;NO, &#x2014;OR, &#x2014;SR, &#x2014;O(CH)OR, or &#x2014;O(CH)O(CH)ORwherein

Growing community of inventors

Oxon, United Kingdom

Richard Edward Armer