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University of Georgia Research Foundation Inc

Richard E Wooley

Branson W Ritchie

Victoria V Burnley

Douglas T Kemp

Anthony C Capomacchia

Emmett B Shotts, Jr

The present invention provides methods and compositions that use the combination of Tris and EDTA to inhibit the growth of microorganisms at the site of a wound or burn, and/or to promote the healing of a wound or burn, and/or to reduce the sensation of pain at the site of a wound or burn. The amount of Tris and EDTA applied to a wound or burn can be selected to achieve one or more of the foregoing effects.

Methods and compositions for promoting wound healing

The present invention relates to novel method of reducing microbial infections, especially bacterial infections, of animals, especially of aquatic animals such as fish maintained in tanks or aquaria. The present invention provides bathing and dipping methods for reducing a microbial infection of an animal with an antibiotic solution of enhanced antimicrobial activity comprising at least one chelating agent and at least one antibiotic effective against the microbial infection. The present invention also provides a method for reducing a microbial infection of an animal comprising bathing or dipping an animal having a microbial infection in an antimicrobial solution comprising the chelating agent EDTA, and at least one antibiotic, and optionally a pH buffering agent. The immersion of the aquatic animal in the antimicrobial solution containing the EDTA, antibiotic and pH buffering agent may be repeated until the microbial burden of the animal is eliminated. The present invention further provides kits for use in administering an enhanced activity antibiotic solution.

Method of treating aquatic animals with an antimicrobial agent and chelating agent

The invention includes novel strains of E. coli and methods for treating livestock with strains of the invention to inhibit growth of S. typhimurium as well as other pathogenic enterobacteria, such as E. coli 0157:H7, in the intestinal tract of treated animals. By inhibiting growth of such contaminant pathogenic organisms in the intestinal tract of treated animals, the number of such organisms living in the animals, or excreted into the environment, is reduced or eliminated. The potential for re-introduction and for contamination of meat and other products is concomitantly reduced or eliminated.

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Athens, GA, United States of America

Richard E Wooley