The University of Texas System

Other

Pharmacyclics, Inc.

Richard E Thomas

Jonathan L Sessler

Brent L Iverson

Vladimir A Kral

Kevin Shreder

Hiroyuki Furuta

Darren Magda

Vladimir A Kr Al

Daniel A Smith

Arthur R Besozzi

Matrix-supported sapphyrins

The present invention provides various novel covalently modified sapphyrin derivatives and conjugates; polymers including sapphyrin or derivatives thereof; and chromatographic supports including sapphyrins and other expanded porphyrins and derivatives thereof. Disclosed are water soluble sapphyrins, including polyhydroxysapphyrins and sapphyrin-sugar derivatives; sapphyrin-metal chelating conjugates; sapphyrin nucleobase conjugates; oligosapphyrins and polysapphyrins, including sapphyrin dimers, trimers, oligomers and higher polymers; and polymer supported expanded porphyrin compositions, including advantageous rubyrin- and sapphyrin-based chromatography columns and electrophoretic supports. Sapphyrin oligomers and polymers and polymer supported expanded porphyrins, such as, e.g., glass and silica expanded porphyrin constructs, are disclosed which include both repeating units of sapphyrin derivatives alone and which include other units, for example, nucleobases, sapphyrin-nucleobase conjugates and long chain alkyl groups.

Method for separating molecules

Method of cleaving DNA

The present invention provides various novel matrix-supported texaphyrins in which a polymeric or solid matrix is covalently modified by the addition of one or more texaphyrins or texaphyrin derivatives. Described are methods of making various polymer-supported texaphyrins, including texaphyrin chromatographic supports, and devices such as catheters, as may be used, for example, in the separation of neutral and anionic species and in applications concerning phosphate ester hydrolysis, other catalytic schemes, MRI, and PDT.

Texaphyrin solid supports and devices

A test assembly for testing regulators and rectifiers. The assembly includes two main components: a modified alternator and a test board. The test board has a regulator test station, which is electrically connected to the rotor of the modified alternator, and it has a rectifier test station, which is electrically connected to the stator of the modified alternator. The modified alternator is run on a conventional alternator tester and its meter observed. This testing assembly allows regulators and rectifiers to be tested individually at a high amperage (full load) before they are assembled into an alternator.

Assembly for testing rectifiers and regulators of automotive alternators

An electrically powered self-heating inoculating loop, including an inoculating loop capable of being heated by passing an electrical current through the loop, and a means for introducing and regulating the electrical current to said inoculating loop.

Electrically powered self-heating inoculating loop

Growing community of inventors

Port Smith, RI, United States of America

Richard E Thomas