Intrexon Corporation

Other

Richard E Peterson

Thomas David Reed

Bethany Lynn Merenick

Robert Beech

Jonathan Carson

Anna P Tretiakova

Elena Tasheva

Joan Mazzarelli Sopczynski

Michael R Sullivan

Charles C Reed

Catherine L Bair

Charles E Reed

Catherine L Keaty

Robert P Beech

The present invention relates to methods and compositions for treating, ameliorating or preventing a disease or disorder in a subject by introducing into cells of the subject a therapeutic gene switch construct that controls expression of one or more therapeutic products.

Therapeutic gene-switch constructs and bioreactors for the expression of biotherapeutic molecules, and uses thereof

The invention relates to mammalian PAI-I ligands and modulators. In particular, the invention relates to polypeptides, polypeptide compositions and polynucleotides that encode polypeptides that are ligands and/or modulators of PAI-I. The invention also relates to polyligands that are homopolyligands or heteropolyligands that modulate PAI-I activity. The invention also relates to ligands and polyligands localized to a region of a cell. The invention also relates to localization tethers and promoter sequences that can be used to provide spatial control of the PAI-I ligands and polyligands. The invention also relates to inducible gene switches that can be used to provide temporal control of the PAI-I ligands and polyligands. The invention also relates to methods of treating or preventing atherosclerosis. The invention also relates to methods of treating or preventing fibrosis.

Polynucleotides encoding therapeutic inhibitors of PAI-1

A building panel for attachment to exterior and interior building surfaces, the panel including a casting layer having at least one imbedded reinforcing layer, at least one attachment means extending through the casting layer and imbedded reinforcing layer for attachment to a building frame, and a finishing layer adjacent to the casting layer, the finishing layer being positioned to cover a first end of the at least one attachment means.

Prefabricated, prefinished reinforced panels for building exterior and interior surfaces and method of manufacture

The earth sheltered building consists of a thin elliptoidal shell which is attached to a generally curvilinear top viewed foundation. The elliptoidal shell meets the foundation at a generally horizontal latitudinal plane which is spacially below and parallel to the equatorial plane of the elliptoid. The building has ingress and egress means defined generally by the intersection of a pair of latitudinal lines and a pair of longitudinal lines of the elliptoid. Ingress and egress means can also be obtained by the omission of any meridian surface section of the elliptoid or any section defined by a plane spacially parallel to a meridian plane. The building can also be elongated by placing a vaulted section of elliptic vertical cross section congruous with two hemi-elliptoidal shells. The building can be constructed by the use of predetermined inner and outer form panels which assemble into inner and outer form networks. These networks are spacially parallel and result in a form system having concavo-convex cavities into which building material is placed. The resultant thin shell elliptoidal structure from the use and method of use of the inner and outer form networks is optimal in distributing the forces that result when the structure is sheltered with earth components such as dirt, gravel, berming, etc. while, simultaneously, providing an interior space which can be optimally utilized for habitation.

Earth sheltered building technology

The anaerobic, displacement-type digester is for the biological production of methane gas. The process involves the anaerobic digestion of solid waste and water or a sewage slurry to produce a methane-rich gas, which can be utilized for its energy value. The digester includes a tank-type enclosure comprising an input end, a digesting chamber and an output end. At the output end a sealable output chamber is provided which can separate the output end from the digesting chamber. The output chamber is comprised of a lower partition and an upper partition, which allows the output chamber to be sealed from the digesting chamber. As waste material is introduced at the input end of the digester, a slurry is formed. The upper stratum of material or scum must periodically be removed from the slurry to provide space for additionally introduced waste into the digester and to optimize the anaerobic digestion process. An upper stratum displacement means is provided at the digesting chamber of the digester. The displacement means removes the upper stratum of material over the lower partition into the output chamber. When the level of material in the output chamber rises to emerge the bottom of the upper partition a seal is formed between the output chamber and the digesting chamber. This seal allows the scum material to be removed from the output chamber without excessive loss of methane gas from nor introduction of air into the digesting chamber of the digester.

Anaerobic digester technology

Growing community of inventors

Blacksburg, VA, United States of America

Richard E Peterson