University of Hawai'i

Eli Lilly and Company

Other

Wayne State University

Richard E Moore

Gregory M Patterson

Jon S Mynderse

Thomas Hughes Corbett

Tim A Smitka

Frederick A Valeriote

Ted R Norton

Trimurtulu Golakoti

Eiichi Furusawa

Roseanne Bonjouklian

Charles D Smith

Susan L Mooberry

Jian Wen Liang

Michael J Martinelli

Vinod Francis Patel

Chuan Shih

John E Munroe

Bryan Hurst Norman

John E Toth

Rosanne Bonjouklian

James E Ray

Eric D Moher

Marcus A Tius

Venkatraghavan Vasudevan

William J Ehlhardt

Thomas K Hemscheidt

Russell A Barrow

Rima S Al-Awar

Subbaraju V Gottumukkala

Lucille H Kimura

Shmuel Carmeli

The present invention provides antitumor methods, formulations, and compounds comprising a cryptophycin.

Cryptophycin compound

Cryptophycin compounds

A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods of producing cryptophycins by total synthesis and methods of using cryptophycins in pharmaceuticals. It is a further object of this invention to use cryptophycins to inhibit the proliferation of mammalian cells. Moreover, methods of using cryptophycins to treat neoplasia is also provided.

Cryptophycins from synthesis

A cryptophycin compound is provided having the structure: ##STR1## Further provided are methods for producing novel cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. Further provided are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.

Cryptophycins

The present invention provides novel cryptophycin compounds having the following structure: ##STR1## The present invention also provides methods for producing cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical compositions comprising novel cryptophycins are also provided by the present invention, as are methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells. The present invention further provides methods for using cryptophycins to inhibit the proliferation of hyperproliferative cells with drug resistant phenotypes, and to treat pathological conditions, such as neoplasia.

Method for producing cryptophycins by cultivating a Nostoc sp.

New hapalindole-type alkaloids called A89271 A-F and I are antifungal and antitumor agents. Methods for preparing them and for preparing hapalindoles G and H by culturing the blue-green alga Fischerella ambigua ATCC 55210 are provided. Methods for preparing A89271 factors B and F by culturing the blue-green alga Hapalosiphon hibernicus ATCC 55225 and a biologically pure culture of this alga are also provided. Further provided are methods and compositions for the inhibition of fungal growth and the treatment of susceptible neoplasms.

A89271 factors and processes for their production

Novel scytophycin compounds and compositions are disclosed, along with methods of making and using the new compounds. Methods for preparing the new scytophycin compounds from new strains of the blue-green algae Scytonema ocellatum, Scytonema burmanicum and purified cultures of the algae are also provided. The scytophycins are useful as anti-cancer agents, antifungal agents and for cell research purposes.

Scytophycin compounds, compositions and methods for their production and

Hapalosiphon hibernicus

Preparation of hapalindole-related alkaloids from blue-green algae

Scytophycins A, B, C, D and E, an aldehyde and alcohol derivative of scytophycin B and the specified alkanoyl and benzoyl esters of scytophycins A, B, C, D and E and the B derivatives (scytophycin compounds) are novel antineoplastic and antifungal agents. Antifungal compositions containing a scytophycin compound and methods of inhibiting fungi, especially plant pathogenic fungi, using these compositions are included. A method for producing the scytophycin complex, comprising scytophycins A, B, C, D and E, using a new strain of the blue-green alga Scytonema pseudohofmanni, and a biologically purified culture of the alga are also provided.

Scytophycins-producing Scytonema pseudohofmanni microorganisms

Scytophycins

New alkaloids called hapalindoles J-Q and T-V, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.

Hapalindoles

New alkaloids called hapalindoles, which are antibacterial and antifungal agents, and methods of preparing these alkaloids by culturing the blue-green alga Hapalosiphon fontinalis ATCC 39694, are provided.

Growing community of inventors

Honolulu, HI, United States of America

Richard E Moore