Medicinova, Inc.

Otologic Pharmaceuticals, Inc.

Richard E Gammans

Kazuko Matsuda

Kenneth Walter Locke

Michael E Kalafer

Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine).

Treatment of progressive neurodegenerative disease with ibudilast

Disclosed herein are compositions comprising a first compound that is N-acetylcysteine or a salt thereof, optionally a second compound that is a pharmaceutically acceptable compound capable of forming a radical adduct; and a coating layer encapsulating at least the first compound. Also disclosed are methods of use and manufacture.

Formulations of n-acetylcysteine and uses thereof

Treatment of amyotrophic lateral sclerosis (ALS) with ibudilast

Compositions and methods for treating progressive neurodegenerative diseases, and their associated symptoms by administration of ibudilast (3-isobutyryl-2 -isopropylpyrazolo[1,5-a]pyridine).

Growing community of inventors

Edmond, OK, United States of America

Richard E Gammans