University of Florida Research Foundation Inc

Glycomed, Inc.

Other

Richard E Galardy

Damian Grobelny

Gregory Scott Schultz

John H Musser

Kevin R Holme

Daniel E Levy

Cho Tang

Asaad Nematalia

Synthetic mammalian matrix metalloprotease inhibitors are disclosed that are useful for treating or preventing diseases wherein said diseases are caused by unwanted mammalian matrix metalloprotease activity and include skin disorders, keratoconus, restenosis, rheumatoid arthritis, wounds, cancer, angiogenesis and shock.

Process for preparing synthetic matrix metalloprotease inhibitors

Synthetic matrix metalloprotease inhibitors and use thereof

Synthetic mammalian matrix metalloprotease inhibitors are useful in controlling angiogenesis. These compounds are thus useful in controlling the growth of tumors and in controlling neovascular glaucomas.

Inhibition of angiogenesis by synthetic matrix metalloprotease inhibitors

Compounds of the formulas ##STR1## wherein R.sup.1 is H and R.sup.2 is alkyl (3-8C) or wherein R.sup.1 and R.sup.2 taken together are --(CH.sub.2).sub.n -- wherein n=3-5;

Treatment for tissue ulceration

Compounds of the formulas ##STR1## wherein each R.sup.1 is independently H or alkyl (1-8C) and R.sup.2 is alkyl (1-8C) or wherein the proximal R.sup.1 and R.sup.2 taken together are --(CH.sub.2).sub.p -- wherein p=3-5;

Matrix metalloprotease inhibitors

Growing community of inventors

Guilford, CT, United States of America

Richard E Galardy