Warner-lambert Company

Usv Pharmaceutical Corporation

Other

Xerox Corporation

Richard E Brown

John Shavel, Jr

Paul C Unangst

Bernard Loev

Chester Puchalski

John H Musser

Vassil St Georgiev

David M Lustgarten

Philip Kropp

Vasil St Georgiev

Howard Jones

Sylvester R Klutchko

Maximilian Von Strandtmann

Fu-chih Huang

Thomas D Lee

Arthur C Fabian

Robert A Mack

Alvin F Morris

Frank Fontsere

New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,

Thiazolo[5,4-h]quinoline compounds useful as anti-allergy agents

New triazoloquinoxalin-1,4-diones are described as well as the use thereof as anti-allergenic agents.

Triazoloquinoxalin-1,4-diones

The quinoline compounds being of the formula: ##STR1## and salts thereof, wherein R.sub.1 and R.sub.2 are independently hydrogen, lower alkyl, halo, trifluoromethyl, amino, lower alkyl amino, lower acylamino, cyano, aryl, aryl/lower alkylene, nitro, lower alkynyl, lower alkenyl, lower alkyl sulfinyl, lower alkyl sulfonyl, lower alkoxycarbonyl, carboxyl, lower alkoxy, lower alkanoyl, or lower alkenoyl,

Imidazo quinoline compounds useful as anti-allergy agents

New quinoline compound, and the corresponding 1,2-; 1,3-; and 1,4-benzodiazines, the quinoline compounds being of the formulae: ##STR1## and salts thereof, wherein R is hydrogen, acyl, carboethoxy,(3-methoxyphen)acetyl,(2-phenyl)propionyl, dimethylcarbamoyl or methyl,

2-Oxo-1,3-oxazolo[4,5-h] quinolines useful as anti-allergy agents

Certain 1,3-oxazolo[4,5H]quinolines useful as anti-allergy agents

Pyridotriazolopyrazine-diones for treating allergy

A new method of treating asthma is provided. The method is the administration of an effective dose of a Benzoxazole-2-carboxylic acid amide.

Method of treating asthma

Provided are imidazoquinoxalines of the structures: ##STR1## wherein R.sub.1, R.sub.5, R.sub.6 and R.sub.7 are independently H, alkyl, aryl, alkenyl, alkynyl, hydroxy, hydroxyalkyl, alkoxy, mercapto, mercaptoalkyl, alkylthio, amino, alkylamino, aminoalkyl, carboxaldehyde, carboxylic acid and salts thereof, carbalkoxy, alkanoyl, cyano, nitro, halo, trifluoromethyl, alkylsulfonyl, sulfonamido, or R.sub.1, R.sub.5, R.sub.6 and R.sub.7 may be taken together with the adjacent group to form a methylenedioxy group. R.sub.4 is H, alkyl, alkenyl, alkynyl, aryl, aralkyl, hydroxy or alkanoyl. R.sub.3 is H, cyano, tetrazolo, carboxaldehyde, hydroxyalkyl, carboxylic acid and salts thereof or derivatives thereof such as esters or amides in which the substituent on the ester oxygen or amide nitrogen is alkyl, aryl, hydroxyalkyl, alkoxyalkyl or amino alkyl. R.sub.2 and R.sub.8 are independently H, alkyl, aryl, halo, amino, alkylamino, arylamino, hydroxyamino, hydroxy, alkoxy, mercapto or alkylthio, and X is oxygen, sulfur, imino, and hydroxyimino.

Imidazoquinoxaline compounds

Provided is a method of treating asthma. The method is the administering to a patient requiring treatment of an effective dose of a benzoxazole-2-carboxylic acid or an ester or therapeutically-acceptable salt of benzoxazole-2-carboxylic acid.

Method of treatment of asthma

Thiazoloquinoxalin-1,4-diones for treating allergy

Certain novel indolopyrone tetrazoles, carboxamidotetrazoles and their pharmaceutically acceptable salts are disclosed. These compounds are useful as antiallergic agents in mammals.

Indolopyrone tetrazoles and carboxamidotetrazoles having antiallergic

Therapeutic compositions containing as active principle, a benzoxazindione or pharmaceutically-acceptable acid addition salt thereof are useful in the treatment of allergy.

Process for treatment of allergic conditions with benzoxazinediones

New benzoxazole-2-carboxylic acid esters are described. These compounds are useful as anti-allergic reagents.

Esters of benzoxa(thia)zole-2-carboxylic acids

Substituted benzopyrano[3,4-c]pyridines and processes for their preparation are disclosed. The compounds are active as bronchodilators.

Substituted benzopyrano[3,4-c]pyridines, compositions and use thereof

This invention relates to novel substituted indolopyrones which have utility in preventing allergic and asthmatic reactions in mammals.

Growing community of inventors

East Hanover, NJ, United States of America

Richard E Brown