Chorda Pharma, Inc.

Richard Daniel Carliss

Jianxing William Huang

Victor Iannello

Stephan Xander Mattheus Boerrigter

Disclosed herein are solid forms containing a compound of formula (I): a solvate, hydrate or isotope thereof, wherein the solid form is characterized by an X-ray powder diffraction pattern having at least one peak position, in degrees 2θ (±0.2°), selected from 5.48, 13.74, 19.22 and 20.06. Also disclosed herein are related pharmaceutical compositions and methods of treatment.

Stable forms of capsaicin palmitate for the treatment of pain

Capsaicin compositions and methods for enhancing hydrophobicity of a molecule useful for pharmaceutical applications, including: (1) a prodrug using a linker such as a carbamate between capsaicin with other structures in order to optimize kinetic control of capsaicin cleavage; (2) a prodrug using a linker such as an unsaturated carboxylic ester between capsaicin with other structures in order to optimize kinetic control of capsaicin cleavage; (3) esters of long-chain fatty acids and capsaicin where hydroxyl groups provide handles for attachment of additional capsaicin molecules; and (4) the use of carboxylic acid diesters to increase overall hydrophobicity of two or more covalently-linked capsaicin molecules. Formulations of palmitated esters of capsaicin are also described, which are designed to enhance hydrophobicity of a molecule useful for pharmaceutical applications, for example to provide compounded mixtures designed to optimize analgesic efficacy.

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Roanoke, VA, United States of America

Richard Daniel Carliss