Battelle Memorial Institute

Mity-lite, Inc.

Other

Olin Corporation

University of Utah Research Foundation

Lineagen, Inc.

H & S Garage Gear, LLC

Ghkn Engineering LLC

Miny-lite, Inc.

University System of Maryland

Richard Dale Smith

Yehia M Ibrahim

Keqi Tang

Gordon A Anderson

Alexandre A Shvartsburg

Ryan T Kelly

Erin M Baker

David J Laws

Sandilya V B Garimella

Harold R Udseth

Orrin Farnsworth

Aleksey Tolmachev

Jason S Page

John L Fulton

Jon Morrell Jacobs

Mikhail E Belov

Ahmed M Hamid

Sandilya Garimella

Tsung-Chi Chen

Venkata B S Garimella

Grant Rogers

Lars J Kangas

William W Smith

Dale Spendlove

James E Bruce

Thomas O Metz

Steve Knowles

Mark A Simon

Ying Zhu

Phillip Swindler

Ailin Li

Kristin E Burnum-Johnson

Chuanliang Liu

R J Cassady

David G Camp, Ii

Xuefei Sun

Weijun Qian

Marina A Gritsenko

Daniel Orton

Taeman Kim

Mark F Leppert

Dean W Matson

David R Goodlett

Charles J Barinaga

Yuehe Lin

Matthew Pectol

Beate Rist

Gregory Wilson

Scott A Shaffer

Ruedi Aebersold

David C Prior

Mikhail B Belov

Jon H Wahl

Jose A Olivares

Wei-Jun Qian

Livingston Elwood Atkins, Iii

Tujin Shi

Aneesh Prabhakaran

Christophe D Masselon

Michael D Brands

Ljiljana Pasa-Tolic

Thomas L Fillmore

Eric J Beckman

Alan L Rockwood

Keith A Consani

Steven A Hofstadler

Ian K Webb

Joanne C Severs

Chenchen Wang

Ashoka D Polpitiya

John Hoidal

Mary Beth Scholand

Michael S Paul

Spencer Posey

Biran H Clowers

Robert Mark Gritz

Konstantinos Petritis

Joel Gardner Pounds

Donald Gerrit Nyberg

Marques B Harrer

Thomas Adrian Groudle

Kenneth J Auberry

Venkata Bs Garimella

Sandilya V Garimella

Methods include directing a group of ions through a separation region of an ion manipulation apparatus, separating the group of ions in the separation region based on ion mobility, selecting a subset of the group of ions based on a dependence between ion mobility and ion arrival time of the separated ions at a deposition switch of the ion manipulation apparatus, and depositing the selected subset of ions on a substrate. Related systems and ion manipulation apparatus are disclosed. Also disclosed are methods and system that provide concurrent ion accumulation and ion separation in coupled and switchable electrode regions using traveling wave electric fields.

Systems and methods for selective molecular ion deposition

Provided herein are methods and systems for biochemical analysis, including compositions and methods for processing and analysis of small cell populations and biological samples (e.g., a robotically controlled chip-based nanodroplet platform). In particular aspects, the methods described herein can reduce total processing volumes from conventional volumes to nanoliter volumes within a single reactor vessel (e.g., within a single droplet reactor) while minimizing losses, such as due to sample evaporation.

Nanoscale biochemical sample preparation and analysis

Methods and apparatuses for ion manipulations, including ion trapping, transfer, and mobility separations, using traveling waves (TW) formed by continuous alternating current (AC) are disclosed. An apparatus for ion manipulation includes a surface to which are coupled a first plurality of continuous electrodes and a second plurality of segmented electrodes. The second plurality of segmented electrodes is arranged in longitudinal sets between or adjacent to the first plurality of electrodes. An RF voltage applied to adjacent electrodes of the first plurality of electrodes is phase shifted by approximately 180&#xb0; to confine ions within the apparatus. An AC voltage waveform applied to adjacent electrodes within a longitudinal set of the second plurality of segmented electrodes is phase shifted on the adjacent electrodes by 1&#xb0;-359&#xb0; to move ions longitudinally through the apparatus for separation.

Method and apparatus for ion mobility separations utilizing alternating current waveforms

Antibody-free processes are disclosed that provide accurate quantification of a wide variety of low-abundance target analytes in complex samples. The processes can employ high-pressure, high-resolution chromatographic separations for analyte enrichment. Intelligent selection of target fractions may be performed via on-line Selected Reaction Monitoring (SRM) or off-line rapid screening of internal standards. Quantification may be performed on individual or multiplexed fractions. Applications include analyses of, e.g., very low abundance proteins or candidate biomarkers in plasma, cell, or tissue samples without the need for affinity-specific reagents.

Process for ultra-sensitive quantification of target analytes in complex biological systems

Apparatus include a plurality of electrode arrangements spaced apart from each other opposite an ion propagation axis and defining an ion transfer channel that extends along the ion propagation axis that tapers between an input end that is situated to receive ions and an output end that is situated to couple the received ions to an input end of an ion guide. Methods include positioning a plurality of electrode arrangements at oblique angles opposite an ion propagation axis so as to form a ion transfer channel that tapers between an input end and an output end, and coupling the output end of the ion transfer channel to an input end of an ion optical element so as to direct ions in the ion transfer channel into the ion optical element. Related systems are also disclosed.

Ion focusing device

Embodiments are directed toward a monopropellant continuous detonation engine. In some embodiments, the continuous detonation engine includes an engine body, a monopropellant feed assembly, and a detonation initiator. The engine body defines a detonation wave channel. The monopropellant feed assembly delivers monopropellant from a monopropellant storage tank into the detonation wave channel. The detonation initiator initiates continuous detonation of the monopropellant in the detonation wave channel, preferably without a catalyst to promote decomposition of the monopropellant. Accordingly, specific impulse is increased compared to constant-pressure reaction thrusters that catalytically decompose the monopropellant with deflagration combustion.

Monopropellant continuous detonation engines

A chair comprises a seat and a backrest carried between opposite frame sides each with a backrest support, a front leg and a rear leg. The seat comprises an upholstered seat cushion disposed on the seat. The upholstered seat cushion comprising a cushion layer carried by a backing and covered by a layer of upholstery. The layer of upholstery extends over the cushion layer and the backing, and wraps around a perimeter of the backing. A snap connection attaches the backing of the upholstered seat cushion to the seat. The snap connection comprises resilient hooks extending from backing of the seat cushion and into holes in the seat.

Cushion for folding chair

Methods and apparatuses for ion peak compression and increasing resolution of ions are disclosed. Packets of ions are introduced into a device. A first electric field is applied for dispersing the ion packets temporally or spatially according to their mobilities. A second intermittent traveling wave is applied for regrouping or merging the dispersed ion packets into a lesser number of trapping regions with narrower peaks. The ions packets are compressed into the narrower peak regions by varying a duty cycle of the intermittent traveling wave.

Method and apparatus for spatial compression and increased mobility resolution of ions

A fluid sample display for displaying actual vehicle fluid samples alongside comparisons of exemplary fluids has a tray with dimples to receive the fluid samples. The dimples are coverable by a movable cover. The tray can have an indicia panel for removably receiving indicia indicative of a vehicle and/or vehicle owner.

Fluid sample display tray

A switch for coupling a first ion manipulation device to a second ion manipulation device comprises a first surface and a second surface, at least one first electrode coupled to each of the first and second surface and configured to receive a first voltage and generate a first potential, and at least one second electrode coupled to each of the first and second surface and configured to receive a second voltage and generate a second potential, wherein the first potential inhibits the motion of ions along a first direction and the second potential inhibits the motion of ions along a second direction different from the first direction.

Methods and systems for integrating ion manipulation devices

An apparatus includes a first pair of opposing electrode arrangements that confine ions between them in a portion of a confinement volume inwardly laterally in a first confinement direction with respect to a longitudinal ion propagation direction, each opposing electrode arrangement including an arrangement of RF electrodes situated to receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes of the arrangement of RF electrodes so as to provide the confining of ions between the first pair of opposing electrode arrangements, and a second pair of opposing electrode arrangements that confine the ions between the second pair in the confinement volume inwardly laterally in a second confinement direction that complements the first confinement direction, each opposing electrode arrangement of the second pair including an arrangement of RF electrodes that receive an unbiased RF voltage having an alternate phase between adjacent RF electrodes.

Device to manipulate ions of same or different polarities

An ion manipulation device comprises a plurality of electrode rings arranged longitudinally adjacent to each other and defining a central axis therethrough. At least one electrode ring comprises a plurality of electrodes arranged in a first planar pattern. Electrodes are configured to periodically receive a voltage to generate a circular traveling wave that rotates around the electrodes of each electrode ring to confine ions within an interior of the apparatus.

Methods and systems for ion manipulation

Growing community of inventors

Richland, WA, United States of America

Richard Dale Smith