University of Illinois

Postech Academy-industry Foundation

Posco

Postech Foundation

Richard D Ye

Pann-Ghill Suh

Sung Ho Ryu

Yoe-Sik Bae

Jong-young Kwak

Jung-Im Kim

Hyun-Kyu Kang

Ni Cheng

Tae Hoon Lee

Rong L He

Ha Young Lee

Eun Jin Jo

The present application discloses W-rich peptide that is useful for inhibiting FPR class receptor activity.

Peptides that antagonize FPR class receptor mediated signaling

The present disclosure relates to compositions and methods of modulating inflammatory and immune responses through binding of SAA to TLR2 in a subject (e.g., human, non-human primate, rodent, etc.), and compositions and methods for screening TLR2 agonists and antagonists. In the studies described herein, a potential role of SAA in neutrophilia was investigated and the results demonstrated that SAA is a potent inducer for macrophage secretion of G-CSF, which leads to neutrophilia in mice. Using G-CSFand TLR2mice, it was found that the SAA-induced neutrophilia is dependent on TLR2-mediated production of G-CSF. Based on direct binding assay and gain-of-function studies in TLR2-transfected cells, SAA was identified as a novel ligand for TLR2 and a link between increased SAA concentration and TLR2-mediated inflammatory responses such as neutrophilia was established. Additional embodiments are disclosed.

Toll-like receptor agonists and antagonists and methods of use thereof

Growing community of inventors

Westmont, IL, United States of America

Richard D Ye