Demerx, Inc.

Stauffer Chemical Company

The United States of America as Represented by the Department of Health

Zeneca Limited

Ici Americas, Inc.

Dynapol Corporation

Other

Richard D Gless

Robert M Moriarty

Deborah C Mash

Nancy Kerlinger

Henry Rapoport

Dwight D Weller

Daniel J Dawson

Robert E Wingard

William C Schinzer

Michael D Broadhurst

Richard W Brown

Jeffrey D Robbins

Peter Karl Wehrenberg

Stephen E Dinizo

William Schinzer

This invention relates noribogaine derivatives, compositions and methods of use thereof.

Substituted noribogaine

Stable noribogaine salt ansolvates are useful for preparing pharmaceutical compositions and for alleviating nociceptive pain in a patient. Such ansolvates can be prepared by slurrying solvated forms, preferably MeOH solvated noribogaine hydrochloride in EtOH/water.

Noribogaine salt ansolvates

Synthetic noribogaine preferably free of ibogaine and, optionally, one or more of other naturally occurringalkaloids, is provided.

Synthetic noribogaine

Disclosed are methods and compositions for preparing and purifying the non-addictive alkaloid noribogaine.

Methods and compositions for preparing noribogaine from voacangine

This invention relates generally to compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier.

Compositions comprising noribogaine and an excipient to facilitate transport across the blood brain barrier

Disclosed herein are phosphate esters of noribogaine and dihydronoribogaine, and esters and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising such compounds, and the methods of their use, including in the treatment of addiction and/or pain.

Phosphate esters of noribogaine

Disclosed herein are sulfate esters of noribogaine or 9,17 dihydronoribogaine, and pharmaceutically acceptable salts of each thereof, pharmaceutical compositions comprising such compounds, and methods of their use, including in treating addiction and/or pain.

Sulfate esters of noribogaine

Disclosed are methods and compositions for purifying the non-addictive alkaloid noribogaine.

Methods and compositions for preparing and purifying noribogaine

Compounds of the formula: ##STR1## wherein R is CH.sub.2 X or CHX.sub.2 and X is chloro or bromo and R.sup.1 is chloro, bromo or nitro which are useful as intermediates for preparing herbicidal 2-(2'-substituted)-4'-(alkylsulfonyl)benzoyl-1,3-cyclohexanedione compounds.

Growing community of inventors

Oakland, CA, United States of America

Richard D Gless