Memory Pharmaceuticals Corporation

Emisphere Technologies, Inc.

Virginia Commonwealth University

Memory Pharmaceutical Corporation

Richard Conticello

Allen T Hopper

Robert F Dunn

Erik Mikal Kuester

Sam J Milstein

Nai Fang Wang

Raphael M Ottenbrite

Jun Liao

John Smart

Eugene N Barantsevitch

Ashok Tehim

Ruiping Liu

Polymeric delivery agents, delivery agent compounds and compositions comprising them which are useful in the delivery of active agents are provided. Methods of administration and preparation are provided as well.

Polymeric delivery agents and delivery agent compounds

Selective PDE4 inhibition is achieved by aryl and heteroaryl pyrazole compounds. The compounds exhibit improved PDE4 inhibition as compared to compounds such as rolipram and show selectivity with regard to inhibition of other classes of PDEs.

Phosphodiesterase 4 inhibitors

Selective PDE4 inhibition is achieved by novel compounds, e.g., 4-(substituted-phenyl)-2-pyrrolidinone compounds. The compounds of the present invention are of formula I: wherein R, R, and Rare as defined herein. The disclosure also relates to methods of preparing such compounds, compositions containing such compounds, and methods of use thereof.

Polymeric delivery agents and delivery agents compounds

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Ossining, NY, United States of America

Richard Conticello