Micromass UK Limited

Waters Technologies Ireland Limited

Richard Chapman

Keith George Richardson

Jeffery Mark Brown

Steven Derek Pringle

Emrys Jones

Paul Robert Murray

Emmy Maria Hoyes

Richard Barrington Moulds

Anthony James Gilbert

Peter Gerard Spreadbury

Paul Doorbar

Phillip Young

Simon Meffan-Main

Phillip Edward Young

Richard Newton

Alan McKinnon

Techniques and apparatus for ion source devices with minimized post-column volumes are described. In one embodiment, for example, an apparatus may include at least one memory, and logic coupled to the at least one memory. The logic may be configured to receive analytical information from at least one analytical instrument, and generate at least one record in a distributed ledger having a transaction associated with at least a portion of the analytical information. Other embodiments are described.

Techniques for managing analytical information using distributed ledger technology

Apparatus is disclosed comprising a first ion source () arranged and adapted to emit a spray of charged droplets () and a detector or sensor () arranged and adapted automatically to detect, sense or determine one or more first parameters or properties of the spray of charged droplets () as the spray of charged droplets () impacts upon a surface of the detector or sensor. The apparatus further comprises a control system () arranged and adapted to adjust, correct and/or optimise one or more second parameters or properties of the spray of charged droplets () based on the one or more first parameters or properties of the spray of charged droplets () detected, sensed or determined by the detector or sensor ().

Ambient ionisation spot measurement and validation

A method of analysing a sample is disclosed that comprises surveying a sample in a first mode of operation by directing a spray of charged droplets onto the sample, determining one or more regions of interest in the sample, and analysing the one or more regions of interest in a second different mode of operation by directing a spray of charged droplets onto the sample. The spot size of the spray of charged droplets at a point of impact with the sample may be varied.

Data directed DESI-MS imaging

A method of mass spectrometry is disclosed that includes transforming mass spectral data to produce frequency-domain mass spectral data, modifying the frequency-domain mass spectral data to produce modified frequency-domain mass spectral data by attenuating and/or removing one or more ranges of the frequency-domain mass spectral data that relate to noise associated with peaks of interest in the mass spectral data, and transforming the modified frequency-domain mass spectral data to produce modified mass spectral data.

Processing mass spectral data

A method of ion imaging is disclosed comprising scanning a sample and acquiring first mass spectral data related to a first pixel location at a first spatial resolution and determining whether or not the first mass spectral data satisfies a condition. If it is determined that the first mass spectral data does satisfy the condition then the first mass spectral data is stored, recorded or prioritized. If it is determined that the first mass spectral data does not satisfy the condition then the first mass spectral data is discarded or downgraded. Scanning of the sample then continues at the first spatial resolution and further mass spectral data related to further pixel locations is acquired.

Data directed storage of imaging mass spectra

A method of ion imaging is disclosed comprising scanning a sample at a first resolution and acquiring first mass spectral data related to a first pixel location. A determination is then made as to whether or not the first mass spectral data satisfies a condition, wherein if it is determined that the first mass spectral data does satisfy the condition then the method further comprises: (i) switching to acquire second mass spectral data related to a second pixel location which is substantially adjacent to the first pixel location so that the second mass spectral data is acquired at a second resolution which is higher than the first resolution; and (ii) determining whether or not the second mass spectral data satisfies the condition, wherein if it is determined that the second mass spectral data does satisfy the condition then the method further comprises acquiring third mass spectral data related to a third pixel location which is substantially adjacent to the first or second pixel locations so that the third mass spectral is acquired at the second resolution and wherein if it is determined that the second or third mass spectral data does not satisfy the condition then the method further comprises switching back to scanning the sample at the first resolution.

Data directed acquisition of imaging mass

A mass spectrometer and methods for controlling a mass spectrometer are provided. In an exemplary embodiment, the mass spectrometer includes a plurality of discrete functional modules, each operable to perform a predetermined function of the mass spectrometer, wherein the modules are individually addressable and connected in a network. The mass spectrometer can also include a scheduler operable to introduce discrete packets of instructions to the network at predetermined times to instruct at least one module to perform a predetermined operation.

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Runcorn, United Kingdom

Richard Chapman