Hamilton Civic Hospitals Research Development Inc.

Mcmaster University

Hamilton Civic Hospitals Research Centre

Mds Ocata, Inc.

Richard Carl Austin

Jeffrey I Weitz

Jack Hirsh

Leslie Berry

Stephen Shaughnessy

Anthony K C Chan

The present invention provides methods for preventing the generation of active thrombin on the surface of cells. The present methods are based upon the surprising discovery that expression or activation of an ER resident chaperone protein in a cell inhibits the generation of thrombin on the surface of the cell. Accordingly, expressing or activating an ER resident chaperone protein can be used to treat or prevent any of a number of thrombotic diseases.

Method of inhibiting the generation of active thrombin on the surface of a cell within an atherosclerotic plaque

There is disclosed a process of treating or alleviating the symptoms of pathological conditions in which bone density is decreased, which comprises inhibiting, in a mammalian patient suffering from such a condition, the formation in vivo of a tertiary complex of IL-11, its cell surface membrane receptor and the cell surface glycoprotein gp130. Examples of such substances are recombinant soluble IL-11 receptor mutants modified, as compared with native IL-11 receptor, at their gp130 binding site, and peptides which can interact with IL-11. The process of the invention not only inhibits bone resorption and hence bone loss, but also increases the process of bone formation to increase bone density.

Osteoporosis treatment

A method for diagnosing hyperhomocysteinemia by molecular genetic means is disclosed.

Methods and compositions for diagnosis of hyperhomocysteinemia

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Ancaster, Canada

Richard Carl Austin