Other

Hemosphere, Inc.

Hemoshpere, Inc.

Richard C Yen

A method and apparatus for large scale production of a product of in vivo medicine carriers for medicine administration. The reagents are prepared in solution and contained in respective bags. A series pumps and mixing chambers are connected to the reagent bags. The pumps are set at pre-determined rates and activated in a pre-determined sequence within respective pre-determined delay periods, to achieve instantaneous component mixing and controlled sequential mixing characteristics.

Large scale production process with instantaneous component mixing and

Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of hemoglobin in the particle composition. Particles which are primarily hemoglobin in the nanometer and micrometer size range in an aqueous suspension are rendered stable against aggregation by the incorporation of either albumin, surface active agents or gelatin.

Method for making non-crosslinked protein particles for therapeutic and

Albumin particles in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolubilization without the aid of a crosslinking agent and without denaturation, by the incorporation of a stabilizing agent in the particle composition. Particles which are primarily albumin in the nanometer and micrometer size range in an aqueous suspension are rendered stable against resolublization by the incorporation of a reducing agent, oxidizing agent, hydrogen-accepting molecule, high molecular weight polymer, sulfur-containing ring compound or combinations thereof.

Non-crosslinked protein particles for therapeutic and diagnostic use

A method and apparatus for large scale production of a product of in vivo medicine carriers which are medicine coated crosslinked protein microspheres for medicine administration. The reagents are prepared in solution and contained in respective bags. A series pumps and mixing chambers are connected to the reagent bags. The pumps are set at pre-determined rates and activated in a predetermined sequence within respective pre-determined delay periods, to achieve instantaneous component mixing and controlled sequential mixing characteristics.

Large scale production of medicine coated crosslinked protein

The present invention is a novel method of producing a unique device of stable porous and membraneless nanomatrixes for carrying medication for in vivo administration. The present invention method produces the device of stable nanomatrixes by mixing a first type of protein which is hemoglobin, a second type of protein which is albumin, and a solution containing an organic solvent which is an alcohol, where the weight ratio of the first and second type of proteins is within the range of approximately 92.+-.5 to 8.+-.5. This results in a turbid suspension of monodispersed nanomatrixes which are typically larger than 1 micron but less than 4 microns in diameter and stable against aggregation and re-solubilization in hypotonic saline for at least 24 hours. An additional solution containing a biologically active substance may be added before or after the solution containing an organic solvent, such that the biologically active substance is entrapped within or bound on the surfaces of the nanomatrixes.

Protein nanomatrixes and method of production

A multi-compartment vacuuming machine which maintains a high flow rate capacity and low resistance from obstructions in the flow path through arrangement of the multiplicity of vacuum canisters in parallel so that obstructed flow in one filter canister will not impair the flow through the remainder of the filter canisters. The flow path of the dirty fluid is arranged such that there is a straight line from the dirty fluid to the most distal filter canister so that the most distal canister fills up first and then intermediate filter canisters are filled. The transverse path leads from the main dirty inlet flow tube to the various filter canisters. In the preferred embodiment, the canister inlet flow tube to each filter canister is generally perpendicular to the dirty air inlet tube and the vacuum suction motor is remote from the most distal of the canisters. Variations on this embodiment include having the canister inlet flow tubes to the various filter canisters set at an angle relative to the dirty air inlet tube, having the vacuum suction motor located adjacent the most distal filter canister, and having the flow path from the dirty air inlet directed in a straight line to one of the filter canisters and therefore generally perpendicular to the flow path of the canister inlet tubes of the other canisters. When a filter canister is filled with particulates, means are provided to shut off air flow to that filter canister and further means are provided to disengage the filter or the filter canister from the vacuum apparatus so that it can be cleaned and if desired the filter can be replaced. In an alternative embodiment, instead of a multiplicity of filter canisters there is a multiplicity of filter compartments in one large enclosure and one sheet filter is used for all compartments.

High capacity low resistance vacuum cleaner

Processes for producing biocompatible and biodegradable protein microspheres with controlled porosity and microsphere sizes are disclosed. Generally, the processes are accomplished as follows: (a) dissolving a source of protein in a mildly acidic or basic aqueous medium, in the presence or absence of a biomodifying agent, (b) adding a cross-linking reagent to the dissolved protein molecules in an amount effective subsequently to cross-link the protein molecules without gelation; (c) adding a water soluble surfactant to modify the surface of the partially cross-linked protein molecules, (d) adding a water soluble organic desolubilizer to desolubilize the protein molecules to allow cross-linkage of nearby protein molecules into water-insoluble microspheres. Alternatively, the cross-linking step of (b) is employed after desolvation of the microspheres. Incorporation of the biomodifying agent, if any, can be achieved by prior bonding to the protein molecules, addition during the formation of microspheres, or addition after the formation of the irreversible and stable microspheres. The microspheres produced by said processes are also disclosed.

Manufacturing protein microspheres

A vacuum cleaner assembly including a multiplicity of vacuum cleaner canister units each of which has a filter for receiving dirty fluid sucked into the canister unit and is configured such that two suction forces operate on each canister unit, with one suction force pulling fluid onto the filter and being of greater force than the second suction force pulling fluid away from the filter and pulling it out of the canister unit to an adjacent canister unit, the filter in each canister unit located in a removable compartment which can be removed when the compartment is filled with dirt, and valve means to turn off the flow into a canister unit after its compartment has been filled with dirt while permitting the vacuum cleaner to continue running and directing the flow of dirty fluid to adjacent canister units with uninterrupted and undiminished suction power.

Method for vacuum cleaner with uninterrupted and undiminished performance

An apparatus for removing a soft stopper such as a cork from a container such as a bottle. The apparatus includes a hollow cylinder having one or more slits along its length and a handle attached to the top of the cylinder. The interior surface of the cylinder includes one or more spiral wound threads having a flat upper surface. The cylinder is inserted between the outer circumference of the cork and the interior wall of the bottle and is rotated so that the threads are embedded in the outer wall of the cork and serve to compress the cork inwardly as the apparatus is screwed into the container. A stop ring serves to limit the penetration of the apparatus into the bottle and when the apparatus has reached its maximum penetration, the apparatus begins to force the cork out of the bottle as the turning motion of the cork continues. Various embellishments serve to enhance the efficiency of operation of the device.

Apparatus for removing a soft stopper from a container

A vacuum cleaner assembly including a multiplicity of vacuum cleaner canister units each of which has a filter for receiving dirty fluid sucked into the canister unit and is configured such that two suction forces operate on each canister unit, with one suction force pulling fluid onto the filter and being of greater force than the second suction force pulling fluid away from the filter and pulling it out of the canister unit to an adjacent canister unit, the filter in each canister unit located in a removable compartment which can be removed when the compartment is filled with dirt, and valve means to turn off the flow into a canister unit after its compartment has been filled with dirt while permitting the vacuum cleaner to continue running and directing the flow of dirty fluid to adjacent cannister units with uninterrupted and undiminished suction power.

Apparatus for vacuum cleaner with uninterrupted and undiminished

A method for filtering a suspension including particulates and increasing the concentration of retainable matter wherein the suspension is drawn through the filter in a manner such that a portion of the suspension is subjected to a negative pressure which pulls it away from the filter membrane and permits it to pass through the filter unit without going through the membrane and a portion of the suspension is subjected to a positive pressure which causes it to pass through the filter membrane before exiting the filter unit, thereby creating a permeate. The invention involves regulation of flow rates to achieve a ratio of the pressures so that when some of the particulate matter from the portion of the suspension passing through the filter membrane becomes effective in decreasing flux, the negative pressure will serve to pull the particulate free and unclog the filter membrane on a continuous and automatic basis, thus allowing prolong filtration time with maximal flux.

Anti-clogging method for maximal flux and prolonged filtration time

An apparatus and method for filtering and dialyzing a suspension including particulates and increasing the concentration of retainable matter wherein the suspension is drawn through the filter in a manner such that a negative pressure gradient is exerted on the suspension to cause the particulates to be drawn away from the filter membrane and avoid clogging the filter membrane. The apparatus comprises a multiplicity of pumps which are located downstream from the filter to thereby suck the suspension out of the filter and away from the filter membrane. The apparatus also comprises a multiplicity of different valve arrangements which permit filtering and dialysis to be performed independently of each other or simultaneously. A multiplicity of different filters, including stacked circular and rectangular filters are utilized such that locations within the system with the greatest clogging potential will be compensated and overcome by a corresponding more negative pressure to decrease the potential of clogging.

Anti-clogging and dialysis device for filtration systems

An apparatus and method for filtering a suspension including particulates and increasing the concentration of retainable matter wherein the suspension is drawn through the filter in a manner such that a portion of the suspension is subjected to a negative pressure which pulls it away from the filter membrane and permits it to pass through the filter unit without going through the membrane and a portion of the suspension is subjected to a positive pressure which causes it to pass through the filter membrane before exiting the filter unit, thereby creating a permeate. The invention involves regulation of flow rates to achieve a ratio of the pressures so that when some of the particulate matter from the portion of the suspension passing through the filter membrane becomes effective in decreasing flux, the negative pressure will serve to pull the particulate free and unclog the filter membrane on a continuous and automatic basis, thus allowing prolong filtration time with maximal flux.

Anti-clogging apparatus and method for maximal flux and prolonged

An apparatus for removing a soft stopper such as a cork from a container such as a bottle. The apparatus includes a hollow cylinder having a slit along its length and a handle attached to the top of the cylinder. The interior surface of the cylinder includes a spiral wound thread having a flat upper surface. The cylinder is inserted between the outer circumference of the cork and the interior wall of the bottle and is rotated so that the threads are embedded in the outer wall of the cork and serve to compress the cork inwardly as the apparatus is screwed into the container. A stop ring serves to limit the penetration of the apparatus into the bottle and when the apparatus has reached its maximum penetration, the apparatus begins to force the cork out of the bottle as the turning motion of the cork continues. In an alternative embodiment, the cylinder includes a hinge which permits the two halves of the cylinder to be opened after the cork is removed from the bottle to thereby enable the cork to be removed from the opened cylinder.

Growing community of inventors

Glendora, CA, United States of America

Richard C Yen