Richardson-Merrell Inc.

Richard C Ursillo

Norbert L Wiech

A method is provided for treating depression in a patient therefrom and requiring rapid symptomatic relief, which comprises administering to said patient concurrently (a) an effective antidepressant amount of a tricyclic antidepressant or a pharmaceutically effective acid addition salt thereof, and (b) an amount of an .alpha.-adrenergic receptor blocking agent effective to achieve rapid onset of the antidepressant action of (a), whereby the onset of said antidepressant action is achieved within from 1 to 7 days. A pharmaceutical composition is also provided which is especially adapted for use with the foregoing method.

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Cincinnati, OH, United States of America

Richard C Ursillo