Pharmacadence Analytical Services, LLC

Ut-battelle, Inc.

Burle Technologies, Inc.

Richard C King, Iii

William Joseph Metzler

Gary J Van Berkel

Bruce N Laprade

Kevin G Owens

The present invention comprises novel methods of continuously monitoring the performance of an atmospheric pressure ionization (API) system. The methods of the invention allow for improved quality monitoring of the processes that leads to the formation of ions at atmospheric pressure. The methods of the invention further allow for continuously monitoring for the quality of the ion formation process in API without the addition of extraneous material (such as labelled compounds or control known compounds) to the system being monitored.

Methods of evaluating performance of an atmospheric pressure ionization system

A method for performing surface sampling of an analyte, includes the step of placing the analyte on a stage with a material in molar excess to the analyte, such that analyte-analyte interactions are prevented and the analyte can be solubilized for further analysis. The material can be a matrix material that is mixed with the analyte. The material can be provided on a sample support. The analyte can then be contacted with a solvent to extract the analyte for further processing, such as by electrospray mass spectrometry.

Enhanced spot preparation for liquid extractive sampling and analysis

A replaceable, electronically-isolated, MCP-based spectrometer detector cartridge with enhanced sensitivity is disclosed. A coating on the MCP that enhances the secondary electron emissivity characteristics of the MCP is selected from aluminum oxide (Al O ), magnesium oxide (MgO), tin oxide (SnO ), quartz (SiO ), barium fluoride (BaF ), rubidium tin (Rb Sn), beryllium oxide (BeO), diamond and combinations thereof A mass detector is electro-optically isolated the from a charge collector with a method of detecting a particle including accelerating the particle with a voltage, converting the particle into a multiplicity of electrons and converting the multiplicity of electrons into a multiplicity of photons. The photons then are converted back into electrons which are summed into a charge pulse. A detector also is provided.

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Quakertown, PA, United States of America

Richard C King, Iii