Fmc Corporation

Calbiochem-behring Corp.

Richard C Hevey

Mark K Malmros

Wayne W Petko

Ronald D Forget

Automated chemical analytical method and device in which a precise measured quantity of reagent is combined with an assay medium. Prior to such delivery, the reagent, being water-soluble or dispersible, is contained within carrier solid organic binder which is fixed within and constitutes part of the device. Upon addition of an aqueous medium, the carrier binder is dissolved or dispersed, the protected precise measured quantity of reagent is concomitantly released and dissolved.

Method and apparatus for chemical analysis using reactive reagents

Device for delivering precise measured quantities of a plurality of reagents with each reagent being incorporated in a device and each being water soluble. The device has a water impervious support secured to one or more faces of which are discrete and separate elements each containing water soluble or dispersible binder and dispersed therein a water soluble or dispersible reagent. The reagent of each element in the device is reactive with at least one constituent in an assay medium or with at least one other reagent on the device. The device is used by contacting it with the assay medium until the elements dissolve completely.

Device for delivering measured quantities of reagents into assay medium

Addition of a low concentration of an alkali metal metabisulfite completely stops color development in a peroxidase-labeled immunoassay wherein the peroxidase catalyzed reaction comprises oxidation of an achromatic substrate to the corresponding chromatic product in the presence of a peroxide.

Method for terminating a peroxidase catalyzed reaction

A method for determining the presence of a ligand in a liquid medium which utilizes enzyme labeled avidin and biotin labeled reagent in a specific binding process wherein the ligand to be detected is contacted with an insoluble phase containing specific binding substance for the ligand. Various protocols may be used to assay the resulting enzyme activity which is related to the amount of ligand in the liquid medium.

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Rockport, ME, United States of America

Richard C Hevey