Sandoz Gmbh

Other

Richard Berthold

William J Louis

Andre Stoll

Franz Troxler

Trevor G Payne

Gerhard Bormann

Jean-Michel Bastian

Max-Peter Seiler

W John Louis

The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

3-aminopropoxyphenyl derivatives, their preparation and pharmaceutical

Compounds of formula (I), ##STR1## characterized in that R signifies optionally substituted heteroaryl-, heteroarylakyl or heteroarylalkenyl, R.sub.1 signifies hydrogen or a substituent, R.sub.2 is hydroxy or a group --z--(CH.sub.2).sub.n --Y--R.sub.3 wherein R.sub.3 is hydrogen, alkyl, hydroxyalkyl, alkenyl, cycloalkyl, cycloalkylalkylene, hydroxy substituted cycloalkyl or cycloalkylalkylene, or optionally substituted aryl or aralkyl or aralkenyl moiety, and Y signifies oxygen or sulfur, and either Z is an oxygen atom and n is 2 or 3, or Z is a bond and n is 1, 2 or 3, A signifies alkylene or branched alkylene of 2 to 5 carbon atoms, W signifies a bond or imino, and X signifies a bond or imino, and their physiologically hydrolyzable derivatives, in which at least one hydroxy group is in esterified form. The compounds exhibit beta adrenoceptor blocking activity. Processes for the preparation of the compounds are also disclosed.

3-aminopropyloxyphenyl derivatives, pharmaceutical compositions

The compounds of formula I, ##STR1## where the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

The compounds of formula I, ##STR1## where the substituents have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterifield form, are useful as cardioselective .beta.-adrenoceptor blocking agents.

The compounds of formula I, ##STR1## wherein the substituents have various significances, and physiologically hydrolyzable derivative thereof having at least one hydroxy group in esterified form, are useful as cardioselective .beta.-adrenoceptor blocking and cardiotonic agents.

Pharmaceutical composition containing as active agents (A) a calcium antagonist of a 4-(2,1,3-benz-oxa- or thiadiazoly)-1,4-dihydro pyridine type and (B) a .beta.-blocker and/or a vasodilating nitrate, effective against coronary heart disease and hypertension.

Pharmaceutical compositions effective against coronary heart disease and

The compounds of formula I, ##STR1## where R.sub.1, R.sub.2 and R.sub.3 have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardiotonic, antiarrhythmic, .alpha.- and .beta.-adrenoceptor blocking agents.

2-Cyano-4-(2-hydroxy-3-substituted-aminopropoxy) indoles

3-Aminopropoxyphenyl derivatives and pharmaceutical compositions

Compounds of formula I ##STR1## wherein (i) m is O, n is 2 and p is 1 or

8'-[(3-Amino-2-hydroxy-propoxy)]-spiro-[cyclopentane-1,2'(1

The compounds of formula I ##STR1## where R.sub.1, R.sub.2 and R have various significances, and physiologically acceptable hydrolyzable derivatives thereof having the hydroxy group in the 2 position of the 3-aminopropoxy side chain in esterified form, are useful as cardiotonic, anti-arrhythmic, .alpha.- and .beta.-adrenoceptor blocking agents.

3-Aminopropoxyaryl derivatives, their preparation and pharmaceutical

The present invention relates to a compound of formula I, ##STR1## wherein A is straight chain alkylene of 2 to 4 carbon atoms, or straight chain alkenylene of 2 to 4 carbon atoms,

Spiro substituted indanones and tetralones

The compounds of formula I ##STR1## wherein R.sub.1 is hydrogen or methyl,

The compounds of formula I ##STR1## wherein R is a group ##STR2## wherein A is alkylene of 2 to 5 carbon atoms,

1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical

This invention provides new compounds of formula I, ##STR1## wherein Het is a radical formed by removing one of the hydrogens from the phenyl ring of 2-indolinone or fluorenone, and

3-Piperidino-2-hydroxypropoxy substituted-2-indolinones

The present invention provides compounds of formula I, ##STR1## wherein R.sub.1 and R.sub.2 are, independently, hydrogen, fluorine, chlorine, trifuoromethyl, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms, and

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Bottmingen, Switzerland

Richard Berthold