E. R. Squibb Sons, Inc.

Richard B Sykes

William L Parker

Wen-Chih Liu

Jerry S Wells

Christopher M Cimarusti

William H Koster

William A Slusarchyk

Pushpa Singh

J Scott Wells

Edward Meyers

Pacifico A Principe

Adrienne A Tymiak

Raymond Cooper

Wen C Liu

Antibacterial activity is exhibited by .beta.-lactams having a sulfonic acid salt substituent in the 1-position and an amino or acylamino substituent in the 3-position.

2-oxo-1-azetidinesulfonic acid salts

Cultivation of the microorganism Chromobacterium violaceum A.T.C.C. No. 31532 yields two novel compounds which have been designated SQ 28,504 and SQ 28,546 in addition to EM5117, a previously disclosed antibacterial compound.

Potentiators of beta-lactam antibiotics

Aerocavin, a novel antibiotic substance having the structure ##STR1## and aerocyanidin, a novel antibiotic substance having the structure ##STR2## can be prepared by cultivation of the microorganism Aerocavin caviae SC 14,030 A.T.C.C. No. 53434.

Aerocyanidin-antibiotic

Aerocavin antibiotics

Cultivation of a strain of the microorganism Pseudomonas cepacia which has been deposited in the American Type Culture Collection as A.T.C.C. No. 39277, yields novel antibiotic substances xylocandin A and xylocandin B having activity against yeasts and fungi.

Antibiotics xylocandin A and xylocandin B

Cultivation of a strain of the microorganism Pseudomonas fluorescens A.T.C.C. No. 39502 yields a novel antibiotic substance 2,3-dihydroxy-N-[2-[(4-nitrophenyl)methyl]-4-oxo-3-oxetanyl]benzamide.

Antibiotic obafluroin

A pharmaceutically acceptable salt of (R)-3-(acetylamino)-3-methoxy-2-oxo-1-azetidinesulfonic acid can be prepared by culturing Chromobacterium violaceum A.T.C.C. No. 31532 at about 25.degree. C. under submerged aerobic conditions on an aqueous nutrient medium containing an assimilable carbohydrate and nitrogen source.

Process for preparing a 2-oxo-1-azetidinesulfonic acid salt

Cultivation of a strain of the microorganism Pseudomonas cepacia SC 11,783, A.T.C.C. No. 39356 yields a novel antibiotic substance which is made up of two compounds, i.e., 5-[3-[3-(hepta-1,2-dien-4,6-diynyl)oxiran-2-yl]-3-hydroxy-1-propanyl]dihyd ro-2(3H)-furanone and 5-[[3-[3-(hepta-1,2-dien-4,6-diynyl)-2-oxiranyl]-2-oxiranyl]hydroxymethyl] dihydro-2(3H)-furanone.

Antibiotic cepacin

Synergistic activity against Candida albicans and Trichomonas vaginalis is obtained when an antifungal imidazole is combined with an antimicrobial agent selected from the group anisomycin, ascomycin, azalomycin F, brefeldin A, copiamycin, EM4940A, or EM4940B.

Synergistic antifungal compositions

Culturing aerobically Erwinia carotovora SC 12,637 A.T.C.C. No. 39048 or Erwinia herbicola SC 12,638 A.T.C.C. No. 39049 in a culture medium containing assimilable carbon and nitrogen sources yields 1-carba-2-penem-3-carboxylic acid.

Process for preparing 1-carba-2-penem-3-carboxylic acid

Culturing aerobically Serratia sp. SC 11,482 A.T.C.C. No. 39006 in a culture medium containing assimilable carbon and nitrogen sources yields 1-carba-2-penem-3-carboxylic acid.

Cultivation of a strain of the microorganism Nocardia sp. 11,340, which has been deposited in the American Type Culture Collection as A.T.C.C. No. 31531, yields a novel antibiotic substance EM 4940, having activity against a range of gram-positive and gram-negative bacteria, yeasts, fungi, acholeplasma, and the protozoan Trichomonas vaginalis.

Process for preparing antibiotic EM 4940

Culturing aerobically Agrobacterium radiobacter no. 31700 in a culture medium containing carbon and nitrogen sources yields the antibiotic substance EM5400, comprising salts of certain azetidinesulfonic acid derivatives.

Process for preparing antibiotics

Cultivation of a strain of the microorganism Nocardia sp. 11,340, which has been deposited in the American Type Culture Collection as A.T.C.C. No. 31531, yields a novel antibiotic substance EM 4940, having activity against a range of gram-positive and gram-negative bacteria, yeasts, fungi, acholeplasma, and the protozoan Trichomanas vaginalis.

3,4-Dihydro-4-hydroxy-5-(3-hydroxy-2-pyridinyl)-4-me

Compounds of the formula ##STR1## wherein R is hydrogen, sodium, potassium, or certain ester groups; R.sub.1 is in the .alpha.-configuration and is hydrogen or methoxy; R.sub.2 and R.sub.3 are independently selected from methyl, ethyl, i-propyl, and n-propyl; R.sub.4 is hydrogen, sodium, potassium or certain ester groups, and X is hydrogen, ##STR2## R.sub.6 is hydrogen or lower alkyl; R.sub.7 is hydrogen, lower alkyl, ##STR3## or --(CH.sub.2).sub.n -N-(lower alkyl).sub.2 ; R.sub.8 is hydrogen, sodium or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as antibacterial agents.

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Belle Mead, NJ, United States of America

Richard B Sykes