Lunar Corporation

Bone Care International, Inc.

Genzyme Corporation

Ge-lunar Corporation

Richard B Mazess

Charles W Bishop

David L Ergun

Joyce C Knutson

Richard Franklin Morris

Scott A Wiener

Joseph P Bisek

James A Hanson

Hector Floyd Deluca

James G Deluhery

John C Gallagher

Mike M Tesic

David M Gauntt

Bernard W Siczek

Daniel R Bullis, Jr

Aldona A Siczek

Stephen Strugnell

Russell H Nord

Larry Fenske

Robert A Washenko

Jeffrey W Driscoll

Charles W Biship

Creighton Reed Goldensoph

Jens Borg

Leon W LeVan

Robert D Schulz

Hector F Deluca

The invention relates to pharmaceutical formulations of lipophilic therapeutic agents in which such agents are solubilized in largely aqueous vehicles, and processes for preparing and using the same.

Formulation for lipophilic agents

The present invention is directed to a conjugate which includes at least one vitamin D moiety thereof and at least one targeting molecule moiety to pharmaceutical compositions of the conjugate, and to methods for using the conjugate for target-specific delivery of vitamin D or analogs thereof to tissues in need thereof. When a particularly preferred form is administered to a patient, the targeting molecule component of the conjugate of this invention seeks out and binds to a tissue of interest, such as bone or tumor tissue, where the vitamin D has a therapeutic effect.

Targeted therapeutic delivery of vitamin D compounds

The invention provides a stabilized 1&#x3b1;-hydroxyvitamin D ('SHVD') which is particularly well suited for pharmaceutical formulations.

Stabilized hydroxyvitamin D

Methods for the utilization of hypocalcemic vitamin D analogs to inhibit the hyperproliferation of malignant or neoplastic cells without incidence of hypercalcemia.

Method of treating hyperproliferative diseases using active vitamin D analogues

A fluoroscopy machine includes an x-ray source and detector mounted in spaced relation to a support arm, an image processor and a display device. The display device includes image optics attached to a head mount wearable by a person, such as a physician or technician. The image displayed by the image optics can be processed by the image processor to present an orientationally accurate image corresponding to the head mount wearer's field of view. For example, the image can be processed to correct for angle of rotation, translation and/or perspective distortion.

Fluoroscopy machine with head mounted display

A meat inspection device uses measurements at two x-ray energies to detect bone in meat samples by determining a mass ratio of bone to meat such as would provide a photoelectric absorption and Compton scattering consistent with the attenuation of the x-rays at the two energies. A relative proportion at different locations can be used to develop an image of the bone. The image can be used to determine whether a product has an unacceptable composition of bone.

Method of inspecting meat for bone content using dual energy x-ray attenuation

Methods utilizing active vitamin D analogs for the inhibition of angiogenesis associated with malignant and neoplasmic cells. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to inhibit the angiogenesis of malignant cells, inducing the apoptosis of malignant cells, and regressing the growth of tumorous cells.

Method of inhibiting angiogenesis using active vitamin D analogues

Methods utilizing active vitamin D analogs for the treatment of malignancy-associated hypercalcemia. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to alleviate hypercalcemia, lower serum parathyroid hormone related protein (PTHrP) levels.

Method of treating malignancy associated hypercalcemia using active vitamin D analogues

The invention provides therapeutic methods for inhibiting, ameliorating or alleviating the hyperproliferative cellular activity of diseases of the prostate, e.g., prostatic cancer and prostatic hyperplasia, which includes administering to a patient in need thereof an active vitamin D analogue. Cell differentiation is promoted, induced or enhanced without causing to the patient dose-limiting hypercalcemia and hypercalciuria.

Method of treating prostatic diseases using active vitamin D analogues

A method of inhibiting the hyperproliferation of malignant or neoplastic cells, comprising treating the cells with an antiproliferative amount of 1&agr;,24(S)-dihydroxyvitamin D . The method also includes the co-administration of cyotoxic angents with the 1&agr;,24(S)-dihydroxyvitamin D .

Methods for preparation and use of 1&agr;,24(S)-dihydroxyvitamin D2

A scanning ultrasonic apparatus provides measurements of a bone at a number of spatially separated locations. These measurements may produce an image or may be used to automatically identify a measurement region of interest or to align a series of measurements with each other despite possible shifting in the bony member in between measurements.

Ultrasonic densitometer with opposed single transducer and transducer array

An ultrasonic instrument employs a digital architecture to provide improved stability to sound speed measurements of human bone in vivo. A digitization of the received ultrasonic signal allows numerical analyses to be applied in determining precise arrival time of the waveform. The microprocessor may initiate the ultrasonic signal transmission and detect its arrival and may control the strength of the transmitted signal and the amplification of the received signal to optimize the signal path.

Digital ultrasonic densitometer

An industrial inspection device uses measurements at two x-ray energy to measure the relative proportions of two materials of a binary industrial composition by determining a mass ratio of a preselected selected first and second material expected to be in the binary composition and such as would provide a photoelectric absorption and Compton scattering consistent with the attenuation of the x-rays at the first and second energy. A relative proportion at different locations can be used to develop an image of one basis material. The image can be used to determine whether a product has an unacceptable composition or inclusions of foreign bodies.

Industrial inspection method and apparatus using dual energy x-ray attenuation

A dual energy scanning densitometry system for imaging and measuring bone density maintains acceptable flux by adjusting the x-ray current or scan speed according to preceding scan line data. The amount of acceptable flux is maintained within limits modified by information about the region of the body being scanned so that different precisions may be maintained for different body regions. Scan speed and current may be controlled so that scan speed is maximized within the current limits. Essentially continuous flux control can be achieved.

Growing community of inventors

Madison, WI, United States of America

Richard B Mazess