Neurocrine Biosciences, Inc.

Other

Richard B Lowe

Martin W Rowbottom

Warren Stanfield Wade

Mi Chen

Timothy Richard Coon

Neil Ashweek

Todd Ewing

Yun-Fei Zhu

Nicole Harriott

Graham Beaton

Wanlong Jiang

Willy Moree

Liren Zhao

Nicole Smith

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure: wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof.

Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

GnRH receptor antagonists are disclosed which have utility in the treatment of a variety of sex-hormone related conditions in both men and women. The compounds of this invention have the structure, wherein R, R, R, R, R, R, and A are as defined herein, including stereoisomers, esters, solvates and pharmaceutically acceptable salts thereof. Also disclosed are compositions containing a compound of this invention in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for antagonizing gonadotropin-releasing hormone in a subject in need thereof. 

Mountable hanger apparatus ( ) and a kit of parts ( ) therefore for affixing preferably to door hinges. The hanger apparatus comprises an elongated member ( ) having top ( ), intermediate ( ), and bottom end member segments ( ), all of which are longitudinally interconnectable along the longitudinal axis ( ) of the elongated member. The elongated member also includes top ( ), intermediate ( ), and bottom ( ) connectors for longitudinally interconnecting the member segments along the member axis. Radially extending support arms ( ) each connect to a connector so as to rotate about the member axis independent of each other. Top and bottom mounting brackets ( ) each slideably receives and connects to a corresponding member segment and also to, for example, a door hinge. The mounting brackets slide along the member segments for adjusting the distance therebetween to fit any door hinge spacing.

Mountable hanger apparatus and kit of parts therefore

Mountable hanger apparatus and a kit of parts therefore for affixing preferably to door hinges. The hanger apparatus comprises an elongated member having top, intermediate, and bottom segments, all of which are longitudinally interconnectable along the axis of the elongated member. Each intermediate segment has end portions each directly interconnectable both rotatably and longitudinally with an end portion of a remaining segment. Preferably, each segment includes a tubular member having a passageway extending therethrough. All but the bottom end segment has one end portion swaged to a reduced diameter for insertion into an unswaged end portion of another tubular member. Resultantly, each intermediate segment can swivel or rotate independent of the top and bottom end segments. Support arms are fixedly attachable to each of the segments of the elongated member, and mounting brackets are fixedly attachable to the top and bottom end segments.

Triple towel bar addition

Hinge mountable rack with swivel loop arms

Hinge mountable rack with swivel arms

A hanging apparatus is disclosed comprising a first end pole and a second end pole with a plurality of middle poles therebetween in axial alignment. Positioned between and pivotably mounted between the end poles and the middle poles are a plurality of hanger bars for receiving an article such as clothing or the like. The hanger bars are free to pivot about the pole axis. The end poles each include an angled bracket which allows the hanging apparatus to be mounted to a door frame between the door and the door frame. In this manner, the hanging apparatus extends away from the door in close proximity to the door frame to allow the hanging of numerous articles without interfering with use of the door. Alternatively, the hanging apparatus and each angled bracket can be mounted directly to a wall to provide for a hanging apparatus to be located in any position on a wall. The hanging bars remain free to be pivoted about the pole axis.

Hanger apparatus and method of mounting the same

Rack

Hinge mountable rack

Growing community of inventors

Indianapolis, IN, United States of America

Richard B Lowe