Ultramet Incorporated

Cytomatrix, LLC

Richard B Kaplan

Robert H Tuffias

Brian E Williams

Michael Rosenzweig

Mark J Pykett

Sebastian Gonnella

Hugh O Pierson

Edwin P Stankiewicz

Andrew J Duffy

Stanley A Racik

J Grady Sheek

John Harding

Walter M Abrams

The invention pertains to methods and devices for the long term, in vitroculture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor cells are cultured on a three-dimensional porous biomaterial. The three-dimensional porous biomaterial enhances hematopoietic progenitor cell survival and leads to an expansion of progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency in the absence of exogenous growth factors. In addition, the three-dimensional porous biomaterial supports high level transduction on cells cultured upon such environment.

Methods and devices for the long-term culture of hematopoietic progenitor cells

The invention pertains to methods and devices for the long term, in vitro culture of hematopoietic progenitor cells in the absence of exogenously added hematopoietic growth factors, improved methods for the introduction of foreign genetic material into cells of hematopoietic origin, and to apparatus for performing these methods. The hematopoietic progenitor cells are cultured on a three-dimensional porous biomaterial. The three-dimensional porous biomaterial enhances hematopoietic progenitor cell survival and leads to an expansion of progenitor cell numbers and/or functionality, while maintaining progenitor cell pluripotency in the absence of exogenous growth factors. In addition, the three-dimensional porous biomaterial supports high level transduction on cells cultured upon such environment.

A refractory composite structure is formed which comprises a ductile refractory metallic layer with a roughened surface which is tightly bonded to a refractory composite structural shell. The roughened surface is preferably dendritic in form and produced by chemical vapor deposition techniques. The refractory composite structural shell is preferably a carbon-carbon composite formed by applying a carbon filament preform to the roughened surface, infiltrating the preform with a carbon matrix precursor, and carbonizing the precursor.

Method of forming a composite structure such as a rocket combustion

A refractory composite structure comprising a ductile refractory metallic layer with a roughened surface which is tightly bonded to a refractory composite structural shell. The roughened surface is dendritic in form and is produced by chemical vapor deposition techniques.

Composite structure

An airbag assembly including an inflatable airbag, an ignitable propellant charge for generating inflating gas and a filter between the interior of the airbag and the propellant charge. The filter comprising a porous carbon foam substrate coated substantially throughout with a thermally and structurally stable material which has been formed in situ by chemical vapor deposition techniques.

Filter and method of forming

A high temperature resistant structure which is capable of withstanding temperatures well in excess of 2500 degrees Fahrenheit in oxidizing environments for periods of at least several hours. A high temperature resistant substrate such as carbon carbon composite is coated in situ with very thin alternate layers of silicon carbide and a carbide formed from hafnium or zirconium. The coating is preferably formed using chemical vapor deposition procedures.

High temperature resistant structure

A tantalum open cell structure is formed by chemical vapor deposition onto a reticulated carbon foam substrate. Tantalum has a long history of use as an implant material, in both bone and soft tissue. This lightweight, strong, porous structure, mimicking the microstructure of natural cancellous bone, acts as a matrix for the incorporation of bone, providing optimal permeability and a high surface area to encourage new bone ingrowth.

Open cell tantalum structures for cancellous bone implants and cell and

A high temperature resistant reticulated porous foam structure for use as a diesel emission particulate trap. A reticulated porous foam substrate which is capable of maintaining its structural integrity at temperatures in excess of approximately 2500, and preferably 2700, degrees Fahrenheit is coated with a formed in situ oxidation resistant coating which extends substantially throughout the interstices of the porous foam structure. The coating comprises very thin alternate layers of silicon carbide and a carbide formed from a Group IVA metal which has a melting point in excess of approximately 1850 degrees Centigrade.

High temperature resistant reticulated foam structure and process

A structure which is resistant to corrosion at high temperatures comprises a ductile layer of a platinum group metal, such as iridium, and a layer of a refractory metal having a high strength at high temperatures, such as rhenium. A solid solution of the two metals is present between and metallurgically bonded to the two metal layers. Further, the structure may include a layer of ceramic such as zirconia or hafnia on the exposed face of the platinum group metal layer.

High temperature corrosion resistant composite structure

A sphere particularly suitable for ball point pens having a core capable of withstanding temperature in excess of 800.degree. C. and a chemically vapor deposited coating on the core, the combined diameter of core and coating ranging from approximately 0.5 to approximately 1 mm in diameter. For example, the core may consist of a metal such as tungsten, nickel, copper or molybdenum; or alternatively the core may consist of a ceramic such as aluminum oxide or graphite. The vapor deposited coating may consist of a metal carbide such as tungsten carbide, titanium carbide, tantalum carbide or niobium carbide. Alternatively the coating may consist of a metal boride such as titanium diboride.

Spheres obtained by vapor deposition for use in ball point pens

A heat radiating coating of rhenium for a refractory core which may be used for a rotating X-ray anode, power tube or the like. The coating is characterized by a multiplicity of needle-like radiation-reflecting elements disposed adjacent to each other. The needles have such steep angles that incoming radiation is substantially absorbed thereby by repeated reflection. Since the coating has a high radiation absorption coefficient it has a corresponding high emissivity on the order of 0.9 at elevated temperatures. A process is disclosed for depositing such a heat radiating coating of rhenium by chemical vapor deposition.

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Beverly Hills, CA, United States of America

Richard B Kaplan