Chirotech Technology Limited

Genzyme Corporation

Chiroscience, Ltd.

Laboratorios Menarini S.a.

Laborabotios Menarini, S.a.

Richard Anthony Wisdom

Caroline Susan Lee

Robert Christopher Brown

Christopher T Evans

Julie Belinda Warneck

Germano Carganico

Chriatopher T Evans

Peter J Stabler

Paul Maurice Ricaud

A lactamase enzyme having good stability, capable of hydrolysing an enantiomer of the bicyclic lactam, 2-azabicyclo&lsqb;2.2.1&rsqb;hept-5-en-3-one, to give (&minus;) lactam and (&plus;) amino acid, has been found in a strain of . The enzyme has been isolated and cloned, and its structure identified.

Microorganism lactamase enzyme obtained therefrom and their use

A lactamase enzyme having good stability, capable of hydrolysing an enatiomer of the bicyclic lactam, 2-azabicyclo[2.2.1]hept-5-en-3-one, to give (-) lactam and (+) amino acid, has been found in a strain of Comamonas acidivorans. The enzyme has been isolated and cloned, and its structure identified.

Microorganism, lactamase enzyme obtained therefrom, and their use

An organism of the genus Ophiostoma or Ceratocystis, or a material having enzymatic activity derived therefrom, is used as a stereo-specific agent, in a biotransformation reaction, for the production of an enantiomeric acid or alcohol from a mixture of enantiomers of an ester thereof.

Stereoselective hydrolysis of chiral carboxylic acid esters using

Enzyme and its use in preparing (S)-pipecolic acid

Ketoprofen resolution by ester hydrolysis using Trichosporon laibacchii

Phosphoenolpyruvate carboxylase (PEPC) characterized by a specific activity of at least 40 units/mg; and/or by no more than 50% loss of activity after 60 days in 167 mM Tricine/HCl buffer, pH 8.0, and 15 mM MgCl.sub.2 ; and/or, at pH 6.5, an activity of at least 40% relative to the activity at optimum pH is disclosed. Such enzymatic activity can be obtained from serine pathway methylotrophs such as Hyphomicorbium, and is very suitable for use in measuring bicarbonate in biological samples.

Bicarbonate assay and phosphoenolpyruvate carboxylase enzyme from

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Cambridge, United Kingdom

Richard Anthony Wisdom