Disarm Therapeutics, Inc.

Richard Andrew Jarjes-pike

Rajesh Devraj

Todd Bosanac

Robert Owen Hughes

Jonathan Bentley

Andrew Simon Brearley

Shelley Anne Parrott

The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing axonal degeneration.

Inhibitors of SARM1

The present disclosure provides compounds and methods useful for inhibiting SARM1 and/or treating and/or preventing neurodegenerative disease or axonal degeneration. The provided SARM1 inhibitors may reduce or inhibit binding of NAD+ by SARM1. Alternatively, provided SARM1 inhibitors bind to SARM1 within a pocket comprising one or more catalytic residues (e.g., a catalytic cleft of SARM1).

Growing community of inventors

Newbury, United Kingdom

Richard Andrew Jarjes-pike