Zoetis Services LLC

Pfizer Corporation

Zoetis LLC

Richard Andrew Ewin

Rajendran Vairagoundar

Timothy Allan Johnson

Graham M Kyne

Paul D Johnson

Susan M K Sheehan

Tomasz Respondek

Michael P Curtis

Nathan Anthony Logan Chubb

Todd M Maddux

Christelle Lauret

Matthew W Bedore

Mark R Cox

Mark Roger Cox

Jerome Sebastien Dauvergne

Govindan Subramanian

Derek James Sheehan

Susan Mary Kult Sheehan

Timothy L Stuk

Brian A Duclos

Christopher A Zook

Eric Baima

Tom L McTier

Susan M Sheehan

Imelda Hot

Michael Kuhn

Hilary Phelps

Jinxia (Nancy) Deng

Christopher Scott Knauer

Michael Curtis

Matthew Frank Brown

Edmund Lee Ellsworth

Ye Che

Tamim F Braish

Justin Ian Montgomery

Usa Reilly

Donald James Skalitzky

Michael Joseph Melnick

John Adam Wendt

Stephen Lee Secreast

Mark Stephen Plummer

Loren Michael Price

Daniel Paul Uccello

Steven X Hu

Susan M Machkovech

Jinxia Deng

Barton H Manning

Tim A Johnson

Ashley E Fenwick

Christoper S Knauer

Timothy Johnson

Susan MK Sheehan

Todd Maddux

Andrea K Haber-Stuk

Richard M Goodwin

Denis Billen

Defined herein are immunomodulating Formula (1) compounds stereoisomers thereof, and pharmaceutically acceptable salts thereof; wherein R, R, R, R, W, Ring C and n are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating o-het/aryl azalides

Defined herein are immunomodulating Formula (1) compounds, wherein R, R, R, R and W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating or preventing an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, or pharmaceutically acceptable salt thereof; or use of said Formula (1) compound to prepare a medicament for treating or preventing an inflammatory and/or immunological disease or disorder in an animal.

Immunomodulating azalides

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R,

Immunomodulating urea azalides

The compounds of the invention, as described herein, are novel serotonin 5-HT2B antagonists useful for the treatment of myxomatous mitral valve degeneration (MMVD), congestive heart failure (CHF), and/or asymptomatic heart failure in animals, preferably canine.

Serotonin 5-HT2B inhibitory compounds

The invention describes novel serotonin c5-HT2B receptor antagonists of Formula (1), and pharmaceutically acceptable salts thereof; wherein Ring A, L, X, X′, R, R, m and n are as defined herein. Also described are compositions comprising a Formula (1) compound, or a pharmaceutically acceptable salt thereof; and methods of using the compounds, or a pharmaceutically acceptable salt thereof, for the treatment of myxomatous mitral valve disease (MMVD), congestive heart failure (CHF) and/or asymptomatic heart failure in animals, preferably is a canine.

Antimicrobial peptides of general formula XXXCXXXCXXXXCYXXCXX(SEQ ID NO: 12) are provided. Also provided are certain formulations containing these peptides and methods of using these peptides for treating skin infections in an animal in need thereof.

Antimicrobial peptides and methods of using same

The present invention is directed to a new fluoro-pyridinone hydroxamic acid phosphates and boronates of Formulae I, II and III wherein Q is selected from the group consisting of —P(O)(OH), —P(O)(OH)(OM), —P(O)(OM)and —P(O)(O)M; Mat each occurrence is a pharmaceutically acceptable monovalent cation; and Mis a pharmaceutically acceptable divalent cation and their use as LpxC inhibitors and, more specifically, their use to treat bacterial infections.

Fluoro-pyridinone phosphates and boronates useful as antibacterial agents

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and L, are as defined herein. The present invention also contemplates compositions and methods of treatment as an endoparasiticide with a Formula (1) compound.

Endoparasitic depsipeptides

The present invention provides cyclic depsipeptides of Formula (1), stereoisomers thereof, and veterinary acceptable salts thereof wherein each of R, R, R, R, L, and Lare as defined herein. The present invention also contemplates compositions, methods of treatment, and uses as a medicament to treat an animal for an endoparasitic infection with a Formula (1) compound.

Defined herein are immunomodulating Formula (1) compounds wherein R, R, R, R, Rand W are as defined herein, stereoisomers thereof, and pharmaceutically acceptable salts thereof; and compositions comprising said compounds. The invention also includes methods for treating an inflammatory and/or immunological disease or disorder in an animal by administering a therapeutically effective amount of a Formula (1) compound, stereoisomer thereof, and a pharmaceutically acceptable salt thereof; or use of said compound of Formula (1) to prepare a medicament for treating an inflammatory and/or immunological disease or disorder in an animal.

Antimicrobial peptides of general formula XXXC XXXCXXXXCYXXCXXare provided. Also provided are certain formulations containing these peptides and methods of using these peptides for treating skin infections in an animal in need thereof.

The invention describes a long-acting veterinary composition comprising at least one ketoprofen ester prodrug. The composition also comprises at least one veterinary acceptable triglyceride, and optionally, at least one preservative, and optionally, at least one additional veterinary acceptable excipient. The invention also describes a method of treating an animal for fever, pain, and/or inflammation by administering the long-acting composition comprising at least one ketoprofen ester prodrug to the animal in need thereof.

Long-acting ketoprofen compositions

The present invention provides Formula (1) compounds that are gamma-carbolines, Formula (1) wherein R1, R1, R1, R1, R2, R3, and '-' are as defined herein; veterinary acceptable salts thereof, and stereoisomers thereof, which act as parasiticides, in particular, endoparasiticides.

Carboline antiparasitics

The present invention provides novel phenicol derivatives, their use for the treatment of infections in mammals, pharmaceutical composition containing these novel compounds, and methods for the preparation of these compounds.

Phenicol antibacterials

Growing community of inventors

Kalamazoo, MI, United States of America

Richard Andrew Ewin