Argentumcidalelectrics, Inc.

Aionx Antimicrobial Technologies, Inc.

North Carolina State University

The Penn State Research Foundation

Wake Forest University

Agentumcidalelectrics, Inc.

Richard A Wysk

Thomas A Fuller

Wayne J Sebastianelli

Robert C Voigt

Paul H Cohen

Anthony Atala

James J Yoo

Sang Jin Lee

Gregory Ray Ziegler

Katie L Basinger

Rohan A Shirwaiker

Matthew C Frank

Caroline Elise Webster

John D Jackson

Molly F Purser

Ola L A Harrysson

Yuan-Shin Lee

Peter M Prim

A method and device for destroying and inhibiting exposure to microbes and infection includes a first element and a second element, and a power source. At least one of the elements includes antimicrobial metal, which, when energized by the power source, produces ions that are lethal to microbes. The device can be incorporated into virtually any useful object. During normal use of the object, electrical communication is established between the two elements, causing current supplied from the power source to flow through the antimicrobial metal. The two elements are configured and arranged to ensure that ions flowing from the antimicrobial metal flow through the region in which it is desired to kill microbes. The antimicrobial metal can be on the surface of the element, incorporated into the material making up the element, or provided in any other way that allows the antimicrobial effect to be achieved.

Ex vivo antimicrobial devices and methods

A medical implant system is described for inhibiting infection associated with a joint prosthesis implant. An inventive system includes an implant body made of a biocompatible material which has a metal component disposed on an external surface of the implant body. A current is allowed to flow to the metal component, stimulating release of metal ions toxic to microbes, such as bacteria, protozoa, fungi, and viruses. One detailed system is completely surgically implantable in the patient such that no part of the system is external to the patient while the system is in use. In addition, externally controlled devices are provided which allow for modulation of implanted components.

Prophylactic bactericidal medical device

Provided herein is a tissue stretching device configured for orbicular expansion of a tissue placed therein. Methods of use of the device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods making use of the same.

Orbicular tissue expander

Prophylactic bactericidal implant

A sprayable liquid coating composition, particularly for application to foodstuffs and pharmaceuticals, utilizes gaseous carbon dioxide to reduce the viscosity of a concentrated solution comprising an edible polymer and a solvent, such as ethyl alcohol or isopropyl alcohol. The addition of the gaseous carbon dioxide in the concentrated solution permits a sprayable composition to be produced using a significantly reduced level of solvent in the edible polymer/solvent solution. By reducing the amount of solvent used in the solution, the level of VOCs emission during the coating process also is reduced. Either supercritical carbon dioxide or subcritical carbon dioxide can be used as the gaseous carbon dioxide in the present invention.

Coating foods and pharmaceuticals with an edible polymer using carbon dioxide

Growing community of inventors

Raleigh, NC, United States of America

Richard A Wysk