The United States of America As Represented by the Secretary of

Iowa State University Research Foundation, Inc.

G.d. Research

Richard A Van Deusen

Prem S Paul

Howard R Shanks

Allen R Landin

Jack J Lyon

Thomas D Hillson

Dennis M Drees

A method and system for detecting material bound on a surface of a piezoelectric resonator introduces a signal of a constant frequency through the sensing resonator and detects a change in the insertion phase shift of the resonator as a result of the binding of the material being detected on the surface of the resonator. Environmental effects on the measurement are effectively canceled by the use of a reference resonator driven by the same input signal. A multiple-port sensing device is provided which includes thin-film sensing and reference resonators monolithically formed on a substrate.

Method and system for detecting material using piezoelectric resonators

A system for analysis of specific binding complexes. A reaction surface is treated with a specific receptor chemical (SRC) having specific binding properties and is allowed to bind with an unknown reactant to form specific binding complexes (SRC) on the reaction surface. The output of a laser is directed through the reaction surface to a detection mechanism. Shadows in the detected light may be interpreted to detect the presence of the unknown reactant. The unknown reactant may also be quantified. Preferred embodiments of apparatus, and methods of their use, are disclosed for detecting the presence of the unknown reactant within a system for interpreting the results, including interactive system components by which the bases for interpretation may be updated.

Apparatus for analysis of specific binding complexes

Monoclonal antibodies which are heavy-chain specific for porcine Ig's are secreted by novel hybrid cell lines produced by fusing SP2/O myeloma cells with B-lymphocytes from BALB/c mice immunized against porcine Ig's. The monoclonal antibodies are useful in porcine immunological research and pathological diagnosis.

Monoclonal antibodies to porcine immunoglobulins

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Ames, IA, United States of America

Richard A Van Deusen