Merrell Dow Pharmaceuticals

Hoechst Marion Roussel

Richardson-Merrell Inc.

Grisar, J. Martin

Dage, Richard C.

Schnettler, Richard a.

Richard A Schnettler

Richard C Dage

Winton D Jones

J Martin Grisar

George P Claxton

Frank P Palopoli

Chi-Hsin Richard King

John T Suh

Timothy A Ayers

Gilbert Marciniak

Johann M Grisar

Richard A Dage

Damian J Krysan

This invention relates to a novel process for preparing 2,3-dihydro-benzofuranol derivatives and to the novel intermediates produced thereby.

Process for preparing 2,3-dihydro-benzofuranol derivatives

Novel 5-acyl-2-(1H)pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.

5-acyl-2-(1H)-pyridinoes

This invention relates to alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones and to their use as cardiotonic agents useful in treating cardiac failure, and to the process useful in the preparation thereof.

Alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones

Novel 5-acyl-2-(1H)pyrdinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.

5-Acyl-2-(1H)-pyridinones useful for treating cardiac failure

Certain alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones

Certain 2-oxo- and 2-thioxoimidazol-4-carboxamides are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.

Method for reducing injury with imidazol-2-thionecarboxamides

Certain imidazol-2-thiones are reported to reduce reperfusion injury which is the injury which occurs when molecular oxygen is reintroduced into an ischemic tissue. These compounds could be used to prevent much of the damage which occurs to the heart of a heart attack victim.

Method of reducing reperfusion injury with imidazol-2-thiones

Novel 5-acyl-2-(1H)-pyridinones and their use as cardiotonic agents. Typical of the compounds is 5-acetyl-1,2-dihydro-6-methyl-2-oxo-3-pyridinecarbonitrile which is prepared by condensing anionic cyano acetamide with 3-[(dimethylamino)methylenyl]-2,4-pentanedione in an inert organic solvent.

Certain 5-acyl-2-(1H)-pyridinones useful in treating cardiac failure

Aroylthiazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.

Cardiotonic aroylthiazolones

Novel alkoxyimino ether derivatives of 5-acyl-2(1H)-pyridinones

A sulfur analog of enoximone, 1,3-dihydro-4-methyl-5-[4-(methylthio)benzoyl]-2H-imidazol-2-thione, is reported to reduce reperfusion injury, the injry which occurs when molecular oxygen is reintroduced into an ischemic tissue. The compound could be used to prevent much of the damage which occurs to the heart of a heart attack victim.

Reducing reperfusion injury with

Alkanoyl or aroyl oxazolones enhance myocardial contractile force and are useful as cardiotonics in the treatment of heart failure.

Cardiotonic alkanoyl and aroyl oxazolones

Phenyloxazolones are useful as cardiotonics in the treatment of heart failure and enhance cardiac function.

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Cincinnati, OH, United States of America

Richard A Schnettler