Other

Johns Hopkins University

The United States of America, as Represented by the Secretary, Department of Health and Human Services

University of Utah Research Foundation

Baylor College of Medicine

Richard A Lewis

Michael C Dean

Mark F Leppert

Rando L Allikmets

James R Lupski

Philip M Smallwood

Jeremy Nathans

Nanda A Singh

Noah F Shroyer

Kent L Anderson

Yixin Li

Amir Rattner

Hui Sun

Arnold Munnich

Annemarie Poustka

Alain Israel

David L Nelson

Nina Heiss

Michele D'Urso

Asmae Smahi

Swaroop Aradhya

Moise Levy

Donald C Forbush

Hayley Woffendin

Sue J Kenwrick

The present invention provides nucleic acid and amino acid sequences of an ATP binding cassette transporter and mutated sequences thereof associated with macular degeneration. Methods of detecting agents that modify ATP-binding cassette transporter comprising combining purified ATP binding cassette transporter and at least one agent suspected of modifying the ATP binding cassette transporter an observing a change in at least one characteristic associated with ATP binding cassette transporter. Methods of detecting macular degeneration is also embodied by the present invention.

Methods of gene therapy using nucleic acid sequences for ATP-binding cassette transporter

Methods of screening and diagnostics using ATP-binding cassette transporter

Nucleic acid and amino acid sequences for ATP-binding cassette transporter and methods of screening for agents that modify ATP-binding cassette transporter

Incontinentia Pigmenti (IP) is a neurocutaneous genodermatosis that segregates as an X-linked dominant disorder with a high probability of prenatal male lethality. A locus in Xq28 containing NF-&kgr;B Essential Modulator, a gene product involved in the activation of NF-kB and central to many pro-inflammatory and apoptotic pathways, contains mutations in the majority of cases of IP. Disclosed are methods, compositions and kits directed to a defect in a NF-&kgr;B related disease such as IP.

Diagnosis and treatment of medical conditions associated with defective NFkappa B(NF-&kgr;B) activation

The present invention is a bracket for mounting a portable cardiac monitor to an ambulance cot. It comprises a lightweight framework having support and restraining members to securely hold a cardiac monitor and which mounts to the side rails and frames of an ambulance cot. A strap is provided to secure the carrying handle of the monitor against the possibility of falling or tipping out of the bracket. The bracket is provided with a pair of upper hook members and a pair of lower hook members to hook over the side rails and frame of an ambulance cot.

Cardiac monitor mounting bracket for ambulance cot

An improved apparatus for burning sulfur to sulfur dioxide and generating sulfurous acid comprising a primary sulfur-burning chamber, a sulfur feed tank closely coupled to the primary chamber, a secondary sulfur burning chamber, and an absorption tower, Air is drawn into the primary chamber under turbulent, high velocity negative pressure conditions. Gas passes through the secondary chamber under turbulent negative pressure flow conditions. The apparatus is capable of converting sulfur to sulfur dioxide at a rate in excess of 25 pounds of sulfur per hour per square foot of surface area of the molten pool of sulfur in the primary chamber.

Sulfur dioxide generator

Growing community of inventors

Houston, TX, United States of America

Richard A Lewis