Vestar, Inc.

Vestar Research, Inc.

Richard A Callahan

George W Tin

Disclosed herein are vesicle compositions for controlled sustained release of an encapsulated therapeutic agent after parenteral administration. By adjusting the osmolarity between the suspending solution and the solution within the vesicles by adjusting the concentration of the suspending solution, the rate of release of the therapeutic agent after parenteral administration can be varied. The compositions can be effectively administered by intramuscular, subcutaneous injection or other means.

Vesicle formulation for the controlled release of therapeutic agents

A method for determining metabolic status of any organism is disclosed. The method is based on determining the changes in rate of oxygen consumption as a function of varying stress levels, and particularly in response to varying the levels of ambient oxygen supply to the organism. Typically, the stress variation is imposed against a backdrop of constant second stress applied to the same organism.

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S. Pasadena, CA, United States of America

Richard A Callahan