Acs Dobfar S.p.a.

Riccardo Monguzzi

Maurizio Zenoni

Antonio Manca

Leonardo Marsili

Giovanni Fogliato

Auro Roberto Tagliani

Gabriele Guastalegname

Bruno Sala

The invention relates to a method for preparing 7-methoxy-3-desacetylcefalotin by a hydrolysis process which takes place in water and is catalyzed by an enzyme obtained frompossessing acetyl hydrolasic activity.

Process for producing 7-methoxy-3-desacetylcefalotin

Cefalotin is methoxylated in position 7&#x3b1;, desacetylated and then carbamoylated in position 3, to provide acid cefoxitin without any isolation of intermediate products. The acid cefoxitin is then transformed into the sodium salt by means of ion exchange resin.

Process for preparing sodium cefoxitin

The invention relates to a method for obtaining cefotetan acid substantially free of tautomer, by treating crude cefotetan with Alions which cause the tautomer to precipitate. The precipitate is eliminated by filtration to provide a solution from which practically tautomer-free cefotetan is obtained.

Process for obtaining cefotetan with high yield

Process for producing Cefepime, Cefpirome and Cefquinome, whereby a cephalosporin containing a quaternary ammonium group is reacted with thiourea to provide the aforesaid cephalosporins.

Process for producing Cefepime and cephalosporin analogues

Cephalosporins may be conveniently prepared by a process in which a benzathinium salt of formula (V) wherein:

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Dorio, Italy

Riccardo Monguzzi