Helsinn Healthcare Sa

Roche Palo Alto LLC

Helsinn Advanced Synthesis Sa

Riccardo Braglia

Roberta Cannella

Daniele Bonadeo

Thomas R Malefyt

Andrew R Miksztal

Silvina Garcia Rubio

Kathleen M Lee

Giorgio Calderari

Fabio Trento

Sergio Cantoreggi

Giorgia Rossi

Alberto Macciocchi

Enrico Braglia

Waldo Mossi

Patrizio Aspari

Roberta Canella

Daniel Beidler

Luigi Baroni

Capsule for pharmaceutical products

The present invention relates to shelf-stable liquid formulations of palonosetron for reducing chemotherapy and radiotherapy induced emesis with palonosetron. The formulations are particularly useful in the preparation of intravenous and oral liquid medicaments.

Liquid pharmaceutical formulations of palonosetron

A process for the preparation of 13-cis-retinoic acid (I) from 3-methyl-5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4-pentadienyl)-triphenylphosphonium chloride (IIa) and 5-hydroxy-4-methyl-2(5H)-furanone (III) is herein disclosed. Compounds (IIa) and (III) are reacted in ethanol as the solvent and KOH as the base at a temperature ranging from &#x2212;5 to 0&#xb0; C. to give a mixture of retinoic acids which is isomerized to (I) by treatment with a palladium complex.

Process for the preparation of 13-cis-retinoic acid

Growing community of inventors

Pazzallo, Switzerland

Riccardo Braglia