The General Hospital Corporation

Massachusetts Institute of Technology

Harvard College

University of Massachusetts

Riccardo Barbieri

Emery Neal Brown

Hani Sallum

James Niemi

Amanda Wozniak

David Paydarfar

Premananda Pai Indic

John Paul Osborne

Luca Citi

Gaetano Valenza

Ruby Kandah

Sandya Subramanian

Hani M Sallum

Systems and methods for tracking sympathetic-driven arousal state (SDAS) including nociception under anesthesia is described herein. The method includes obtaining heart rate variability and electrodermal activity of a subject. Point process models are generated for the heart rate variability and the electrodermal activity. A multimodal approach is implemented to determine a state space framework based on these point process models. SDAS can be estimated using the state space framework. In some implementations, an anesthesiologist can modify the dosage of drugs administered to the subject based on this estimation.

Tracking nociception under anesthesia using a multimodal metric

A system and method for analyzing a subject health condition based on an input signal comprising subject heartbeat data recorded from the subject over a time period. Using the subject heartbeat data, a sympathetic activity index value in a sympathetic activity index (SAI) determined, where the SAI represents an influence, on a mean heart rate of the subject, of sympathetic nerve activity (SNA) of the subject.

System and method for sympathetic and parasympathetic activity monitoring by heartbeat

Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation.

Systems and methods for inhibiting apneic events

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Boston, MA, United States of America

Riccardo Barbieri