Alphora Research Inc.

Sandoz Ag

Ricardo Orprecio

Boris Gorin

Fabio E S Souza

Jason A Bexrud

Ming Pan

Alena Rudolph

Huzaifa Rangwala

Teng Ko Ngooi

Jan Oudenes

Fabio Eduardo Silva E Souza

Navindra Jainarine Ramjit

Jason Edward Field

Fabio Es Souza

Emma-Louise Moore

Fabio ES Souza

Disclosed are salts of a compound of formula 1, as shown below, where R, R, R, R' R, Rand Rare as described herein. Also, disclosed is a process for the preparation of the salts of the compounds of formula 1, and intermediates used therein. The salts of the compound of formula 1 can be useful for preparation of halichondrin analogs such as eribulin. 

Crystalline derivatives of (S)-1-((2R,3R,4S,5S)-5-allyl-3-methoxy-4-(tosylmethyl)tetrahydrofuran-2-YL)-3-aminopropan-2-ol

Disclosed is a compound of formula 1, or a pharmaceutically acceptable salt thereof, where R, R, R, R, R, R, R, R, R, R, R, R, Rand Rare as disclosed herein. Also, disclosed is a process for the preparation of the compound of formula 1, or a pharmaceutically acceptable salt thereof, and intermediates used therein. The compound of formula 1 can be used in the preparation of halichondrin analogs, such as Eribulin; and a process for its preparation from the compound of formula 1 is also disclosed. 

Synthetic process for preparation of macrocyclic C1-keto analogs of halichondrin B and intermediates useful therein

Discloses is a process for preparation of a compound of formula 11, or a derivative thereof, wherein PGis an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 11 can be useful in the preparation of halinchondrin analogs. 

3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives, their preparation and intermediates useful thereof

Discloses is a process for preparation of a compound of formula 7, or a derivative thereof, wherein PGis an alcohol protecting group. Also, disclosed are intermediates and processes for their preparation. The compound of formula 7 can be useful in the preparation of halinchondrin analogs such as Eribulin. 

Process for preparation of 3-((2s,5s)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof

Process for preparation of 3-((2S,5S)-4-methylene-5-(3-oxopropyl)tetrahydrofuran-2-yl)propanol derivatives and intermediates useful thereof

An individual tetrahydrocannabinol isomer of interest is separated from a mixture containing two or more such isomers, by treating the mixture with an isocyanate or isothiocyanate of formula I:R&#x2014;(CH)&#x2014;N&#x2550;C&#x2550;X&#x2003;&#x2003;(I)where R represents an aromatic ring optionally substituted with one or more electron withdrawing groups, n=0 or 1 and X is oxygen or sulphur; so as to produce a crystallizable THC carbamate of formula II: wherein X and R are as defined above, R' is a C-Calkyl group and the dotted lines indicate optional unsaturation including aromatic, separating the compound of formula II from solution in isolation of other THC derivatives, and hydrolyzing the compound of formula II to form the individual tetrahydrocannabinol isomer of interest.

Separation of tetrahydrocannabinols

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Etobicoke, Canada

Ricardo Orprecio