Astrazeneca Ab

Rhony Aufdenblatten

Martin Hans Bohlin

Ulf G Larsson

Laurent Ducry

Mattias Magnusson

Ulrika Lindblad

Thomas Peter Belser

Wilhelm Quittman

Andreas Weiss

Mikaela Recknagel

Peter W Johansson

Helena Hellström

Helena Hellstroem

Andreas (deceased) Weiss

Helena HELLSTRÖM

Ursula Heiress Of Weiss Andreas Weiss

The present invention is directed to a process for preparing [1S-[1&#x3b1;,2&#x3b1;,3&#x3b2;(1S*,2R*),5&#x3b2;]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol and to intermediates useful in the process.

[object Object]

Aromatic or heteroaromatic nitro compounds are catalytically hydrogenated to the corresponding amines in the presence of a platinum catalyst comprising elemental platinum on a support; the platinum catalyst is modified with a molybdenum compound and a phosphorus compound wherein the phosphorus has an oxidation state of less than +5, e.g. hypophosphorous acid; the catalyst is particularly useful in the hydrogenation of nitro compounds with halogen and/or sulfur-containing substituents.

Process and catalyst

The present invention is directed to a process for the preparation of a diastereomerically pure dibenzoyl-L-tartrate salt of a compound of formula (III) and to products of said process.

Process 054

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Visp, Switzerland

Rhony Aufdenblatten