Novartis Vaccines & Diagnostics, Gmbh

Rhonda Hansen

Christoph Reinhard

Giulia C Kennedy

Jaime A Escobedo

Filippo M Randazzo

Joerg Kaufmann

Vivien W Chan

Pablo Dominguez Garcia

George Lamson

Julie Sudduth-Klinger

Edward J Moler

Deborah Lee Zimmerman

Jill Winter

Shuling Fang

The present invention provides polynucleotides, as well as polypeptides encoded thereby, that are differentially expressed in cancer cells. These polynucleotides are useful in a variety of diagnostic and therapeutic methods. The present invention further provides methods of reducing growth of cancer cells. These methods are useful for treating cancer.

Gene products differentially expressed in cancerous cells

The invention provides, inter alia, models of bone metastasis, methods for identifying agents that modulate skeletal related events and metastasis, methods for modulating skeletal related events and metastases, and methods for detecting skeletal related events and metastases. The methods and models generally comprise co-culturing cancer cells and host cells and comparing biological markers from such co-cultured cells to control cells.

Methods of modulating metastasis and skeletal related events resulting from metastases

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Emeryville, CA, United States of America

Rhonda Hansen